PMID: 7017170Jun 1, 1981Paper

A comparison of hydroxyurea, methyl-chloroethyl-cyclohexy-nitrosourea and cyclophosphamide in patients with advanced carcinoma of the prostate

The Journal of Urology
S A LoeningG P Murphy

Abstract

This is the fifth completed randomized clinical trial of the National Prostatic Cancer Project. There were 125 patients with histologically confirmed relapsing clinical stage D prostatic cancer randomized to receive hydroxyurea, methyl-chloroethyl-cyclohexy-nitrosourea or cyclophosphamide. All patients had received and failed previous hormonal therapy. Patients whose disease progressed after 12 weeks on the initial therapy were crossed over or randomized to receive an alternate drug. There were 98 patients available for comparison of treatments. Objective responses included patients with complete or partial regression as well as stable disease. The response rates were 35 per cent for cyclophosphamide, 30 per cent for methyl-chloroethyl-cyclohexy-nitrosourea and 15 per cent for hydroxyurea. Subjective response parameters included improvement in performance status and relief of pain. Pain was improved in a fifth of the patients on each treatment area. Methyl-chloroethyl-cyclohexy-nitrosourea and hydroxyurea showed activity in advanced prostatic cancer patients but at the expense of excessive toxicity. Cyclophosphamide continues to be the most active single agent in this type of patient, particularly with regard to duration of res...Continue Reading

Citations

Sep 15, 1983·International Journal of Cancer. Journal International Du Cancer·S A MetcalfeB T Hill
Nov 1, 1993·British Journal of Urology·D RaghavanJ J Grygiel
Jan 1, 1984·The Prostate·N H SlackG P Murphy
Mar 11, 2005·Expert Review of Anticancer Therapy·Teodoro SavaGian Luigi Cetto
Oct 21, 2006·The Cochrane Database of Systematic Reviews·Mike ShelleyMalcolm D Mason
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·R Rago
Sep 3, 2011·Asia-Pacific Journal of Clinical Oncology·S C-H KaoG Marx
Sep 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S SantarossaU Tirelli
Nov 7, 1998·Cancer Treatment Reviews·A J Dowling, I F Tannock

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