A comparison of imipenem/cilastatin with the combination of cefuroxime and metronidazole in the treatment of intra-abdominal infections

Scandinavian Journal of Infectious Diseases
M AngeråsJ B Holme

Abstract

515 patients with intra-abdominal infection participated in an open randomized comparative multicenter trial in order to compare the efficacy, safety, and tolerance of imipenem/cilastatin with cefuroxime/metronidazole. 258 patients (mean age 56 years) received imipenem/cilastatin 1.5-2.0 g/day, and 257 patients (mean age 54 years) received cefuroxime 3.0-4.5 g/day plus metronidazole 1.0-1.5 g/day for at least 3 days. 130/161 evaluable patients (80.8%) receiving imipenem/cilastatin and 124/145 evaluable patients (85.5%) receiving cefuroxime/metronidazole were clinically cured. The microbiological response was favorable in 86.9% in the imipenem/cilastatin group and in 90.8% in the cefuroxime/metronidazole group. The two treatment groups were similar with respect to median time to defervescence which was 4 days. The median duration of treatment was 6 days and the median time to discharge from hospital was 9 days in both groups. Drug-related adverse reactions were observed in 14 patients receiving iminpenem/cilastatin and in 8 patients receiving cefuroxime/metronidazole. 19 patients in the imipenen/cilastatin group and 12 patients in the cefuroxime/metronidazole group died. No correlation was found between the deaths and the study ...Continue Reading

References

Sep 1, 1978·The Journal of Antimicrobial Chemotherapy·S J Eykyn, I Phillips
Nov 1, 1991·Annals of Surgery·D M MosdellD E Fry
Feb 1, 1989·Antimicrobial Agents and Chemotherapy·L KagerC E Nord
Feb 1, 1988·Archives of Surgery·J M BohnenB D Schouten
Aug 1, 1987·European Journal of Clinical Microbiology·D M Livermore
Feb 1, 1988·The British Journal of Surgery·Moshe ScheinG A Decker
Sep 1, 1986·Journal of Bacteriology·E Tuomanen, A Tomasz
Dec 1, 1986·American Journal of Surgery·C AndrusD L Kaminski
Jul 1, 1985·Reviews of Infectious Diseases·S R Norrby
Jun 7, 1985·The American Journal of Medicine·R N Jones
Jan 1, 1985·Archives of Surgery·E Patchen DellingerR L Simmons
Feb 1, 1983·Archives of Surgery·H H StoneW E Dunlop
Nov 1, 1984·Antimicrobial Agents and Chemotherapy·C I BustamanteH C Standiford
Mar 1, 1983·Archives of Surgery·J M BohnenA P McLean
Feb 1, 1980·The Surgical Clinics of North America·W A Altemeier
Mar 1, 1982·Archives of Surgery·W D Pitcher, D M Musher
Jul 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G S CooperR A Salata

Citations

Jan 25, 2003·Surgical Infections·John E MazuskiTherapeutic Agents Committee of the Surgical Infections Society
Jan 25, 2003·Surgical Infections·John E MazuskiTherapeutic Agents Committee of the Surgical Infections Society
Jul 6, 2012·Clinical Microbiology Reviews·Pranita D TammaLisa L Maragakis
Oct 3, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinInfectious Diseases Society of America
Mar 13, 2008·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·P KujathA Rodloff
Dec 19, 2009·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·K-F Bodmann, und die Expertenkommission der Infektliga
Mar 29, 2011·Critical Care Clinics·Cybéle L AbadNasia Safdar
Mar 18, 2000·Journal of Chemotherapy·M E Cinat, S E Wilson
Jan 30, 2007·Expert Opinion on Pharmacotherapy·Ioannis P KioumisDavid P Nicolau
Apr 23, 2005·The Cochrane Database of Systematic Reviews·P F WongD J Leaper
Dec 26, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Joseph S SolomkinJohn G Bartlett
Dec 29, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Xiuwen WuJianan Ren

Related Concepts

Abdomen
Bacterial Infections
Zinacef
Polychemotherapy
Bayer 5360
Fungus Drug Sensitivity Tests
Cilastatin Sodium
Imipenem, Anhydrous
Abdominal Abscess

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