A comparison of ketamine-midazolam and ketamine-medetomidine combinations for induction of anaesthesia in rabbits

Veterinary Anaesthesia and Analgesia
N J Grint, Pamela J Murison

Abstract

To compare ketamine-midazolam (KMZ) and ketamine-medetomidine (KMT) anaesthesia in rabbits using anaesthetic induction, maintenance and recovery data. Randomized, prospective, blinded clinical trial. Fifty rabbits (25 male, 25 female) of different breeds undergoing ovariohysterectomy or castration. Rabbits were 12.7 +/- 9.8 months old with body mass 2.24 +/- 0.61 kg. Randomized, prospective, blinded clinical trial. Ketamine (15 mg kg(-1)) and midazolam (3 mg kg(-1)) or medetomidine (0.25 mg kg(-1)) were administered by intramuscular (IM) injection. Ten minutes after IM injection, blind intubation of the trachea was attempted. The time taken, the number of attempts and a subjective score of the ease of intubation were recorded. Isoflurane (range 0-3.6%) in 100% oxygen was delivered via a Jackson Rees modification of an Ayre's T-piece non-rebreathing system. Carprofen (3 mg kg(-1)) and dextrose saline (5 mL kg(-1) hour(-1)) were administered intravenously (IV). During surgery heart rate (HR), respiratory rate (RR) and arterial oxygen saturation of haemoglobin (SpO(2)) were monitored. Times to extubation and first head lift were recorded. Group KMT received atipamezole (0.5 mg kg(-1)) IM 30 minutes after discontinuation of isoflur...Continue Reading

References

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Apr 21, 2007·Veterinary Anaesthesia and Analgesia·Nicola J Grint, Pamela J Murison
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Citations

Nov 16, 2010·The Veterinary Clinics of North America. Exotic Animal Practice·Linda S Barter
Jan 10, 2009·The Veterinary Clinics of North America. Exotic Animal Practice·Romain Pariaut
Mar 17, 2010·Veterinary Anaesthesia and Analgesia·Kathy L MurphyPaul A Flecknell
Nov 30, 2014·The Veterinary Record·Minh HuynhLuca Zilberstein
Apr 27, 2017·Frontiers in Veterinary Science·Sarah EngbersDaniel S J Pang
Jan 15, 2010·Laboratory Animals·Sandra AllweilerPaul A Flecknell
Nov 7, 2019·Animals : an Open Access Journal From MDPI·Mathieu RaillardNikola Saulacic
Jul 6, 2019·Journal of Veterinary Research·Güneri AtalanIhsan Keleş
Oct 23, 2009·Veterinary Anaesthesia and Analgesia·Adetola R AjadiFolashade A Makinde

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