PMID: 11923050Mar 30, 2002Paper

A comparison of mechanical and laser transmyocardial revascularization for induction of angiogenesis and arteriogenesis in chronically ischemic myocardium

Journal of the American College of Cardiology
G Chad HughesJ E Lowe

Abstract

The purpose of the present study was to compare the use of a mechanical transmyocardial implant (TMI) device with transmyocardial laser revascularization (TMR) for induction of therapeutic angiogenesis and arteriogenesis in the chronically ischemic heart. Prior experimental studies have demonstrated evidence for neovascularization after both mechanical and laser transmyocardial revascularization, although a long-term comparison of the two techniques has not been performed. Using an established model of chronic hibernating myocardium, mini-swine underwent 90% proximal left circumflex (LCx) coronary artery stenosis. One month later, baseline positron emission tomography (PET) and dobutamine stress echocardiography (DSE) were performed to quantitate regional myocardial blood flow (MBF) and function. Animals then underwent TMR with a holmium:yttrium-aluminum-garnet (holmium:YAG) laser (n = 5), TMI (n = 5), or sham redo-thoracotomy (n = 5). In the TMR group, the entire LCx region was treated with transmural laser channels at a density of 1/cm(2). Transmyocardial implants were placed transmurally at a similar density in the LCx region of the TMI group. Six months later, the PET and DSE studies were repeated, and the animals were euth...Continue Reading

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Citations

Sep 21, 2010·BMC Cardiovascular Disorders·Guillermo ReyesJuan Duarte
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Pavan AtluriY Joseph Woo
Jul 26, 2006·The Annals of Thoracic Surgery·Louis A BrunstingChad R Swan
Mar 3, 2004·The Annals of Thoracic Surgery·G Chad HughesKevin P Landolfo
Jan 1, 2009·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Pavan AtluriY Joseph Woo
Apr 28, 2004·Journal of Cardiac Surgery·G Chad HughesKevin P Landolfo
May 14, 2005·Expert Review of Cardiovascular Therapy·G Chad Hughes, Brian H Annex
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Mar 7, 2006·Expert Review of Medical Devices·Keith B Allen
Dec 1, 2018·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Keith B AllenA Michael Borkon
Jul 14, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·James P TastoDavid Amiel

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