A comparison of mechanical valve performance in a poorly anticoagulated community

Journal of Cardiac Surgery
M A WilliamsS Van Riet

Abstract

This study was undertaken to evaluate the clinical performance of the Carbomedics, Medtronic Hall and On-X valves in the challenging setting of a Third World population with incomplete anticoagulation coverage. In the Carbomedics group 140 valves were implanted in 126 patients (aortic 30, mitral 82, and aortic and mitral 14), 39% were adequately anticoagulated. Follow-up was 89% complete for a total of 216 patient-years. In the Medtronic Hall series 224 valves were implanted in 198 patients (aortic 50, mitral 122, and aortic and mitral 26), 39% were adequately anticoagulated. Follow-up was 93% complete for a total of 459 patient-years. In the On-X series 252 valves were implanted in 200 patients (aortic 44, mitral 104, and aortic and mitral 52), 58% were adequately anticoagulated. Follow-up was 94% complete for a total of 2217 patient-years. Hospital mortality was 2.4% (3 patients) in the Carbomedics group, 3.9% (9 patients) in the Medtronic Hall group, and 2.0% in the On-X group. None of the hospital deaths were valve-related. The linearized rates for late complications in the mitral position (percent per patient-year) were, respectively, for the Carbomedics (CM), the Medtronic Hall (MH), and On-X valves-thromboembolism: 1.4 (...Continue Reading

References

Oct 1, 1995·The Annals of Thoracic Surgery·A E FianeT Frøysaker
Aug 1, 1994·The Annals of Thoracic Surgery·N K ReddyB S Raju
Dec 1, 1996·Artificial Organs·S S WangF Y Lin

❮ Previous
Next ❯

Citations

Mar 10, 2006·Current Cardiology Reports·Joseph Huh, Faisal Bakaeen
Jun 16, 2010·The Journal of Thoracic and Cardiovascular Surgery·Vincent ChanThierry G Mesana
Oct 24, 2007·Biomaterials·Peter ZillaDeon Bezuidenhout
Jan 30, 2007·The Annals of Thoracic Surgery·Dirk FritzscheReiner Koerfer
Apr 8, 2015·Annals of Cardiac Anaesthesia·Ami M KarkarShvetank Agarwal
Apr 3, 2012·International Journal of Cardiology·Maurizio FerratiniLuigi Martinelli
Nov 29, 2007·Anesthesia and Analgesia·David A Pybus
Nov 27, 2007·Expert Review of Cardiovascular Therapy·Mark S Slaughter, Eias Jweied
Aug 16, 2018·The Journal of Thoracic and Cardiovascular Surgery·Jacques SchermanPeter Zilla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.