A Comparison of Methods for Tracking Progression in X-Linked Retinitis Pigmentosa Using Frequency Domain OCT

Translational Vision Science & Technology
Rithambara RamachandranDonald C Hood

Abstract

To compare the efficacy of frequency domain optical coherence tomography (fdOCT)-derived outer retinal measures in tracking disease progression in x-linked (xl) retinitis pigmentosa (RP) patients. Macular volume scans and line scans (Spectralis) were obtained from 27 xlRP patients (15.3 ± 6.4 years) at two visits approximately 2 years apart. Changes in average outer retinal layer thicknesses across the volume scan were compared to changes detected by measures derived from the edge of the inner segment ellipsoid zone (EZ) band, that is, where the EZ band (also known as inner segment/outer segment border) disappears. Repeatability was tested on an independent set of 18 RP patients (43.5 ± 18.0 years). Average outer segment (OS) and outer nuclear layer (ONL) thickness showed marginally significant annual changes (P < 0.05), while total receptor (TR) thickness showed a greater change (P < 0.01). All measures derived from the edge of the EZ band significantly decreased (P < 0.01). Mean ± SD for test-retest differences in horizontal widths was 0.01 ± 0.06 mm. Measures of the EZ band are more effective in detecting disease progression than are thickness measures. Given the similar effectiveness of line and volume scans, manually marki...Continue Reading

References

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Apr 4, 2008·Investigative Ophthalmology & Visual Science·Tomas S AlemanSamuel G Jacobson
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Nov 16, 2010·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Donald C HoodMin Wang
May 12, 2011·Biomedical Optics Express·Donald C HoodVivienne C Greenstein
Aug 4, 2011·Investigative Ophthalmology & Visual Science·David G BirchDonald C Hood

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Citations

Mar 10, 2016·Seminars in Ophthalmology·Brian P HaflerEric A Pierce
Jul 15, 2015·American Journal of Ophthalmology·Tharikarn SujirakulStephen H Tsang
Feb 6, 2015·Translational Vision Science & Technology
Jan 31, 2017·Genes·Jesse D SengilloStephen H Tsang
Jun 9, 2018·Translational Vision Science & Technology·Margaret R StrampeJoseph Carroll
Jun 20, 2020·Ophthalmic Genetics·Jin Kyun OhStephen H Tsang
Aug 21, 2020·Translational Vision Science & Technology·Yi-Zhong WangDavid G Birch
Jun 19, 2019·Translational Vision Science & Technology·Travis B SmithNing Smith
Apr 3, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Shunji NakatakeYasuhiro Ikeda
Dec 30, 2020·Investigative Ophthalmology & Visual Science·Valentina Di IorioFrancesca Simonelli
May 14, 2021·The British Journal of Ophthalmology·Malena Daich VarelaMichel Michaelides
Jul 23, 2021·Ophthalmic Genetics·Dhimas H SaktiJohn R Grigg
Sep 16, 2021·Annual Review of Vision Science·Sarah R LeviStephen H Tsang
Sep 30, 2021·International Ophthalmology Clinics·Daniel C ChungRobert E MacLaren

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