PMID: 1424643Jan 1, 1992

A comparison of metronidazole distribution following intravenous metronidazole and metronidazole phosphate disodium in mice

Drug Metabolism and Drug Interactions
T Li, S Qu


The distribution of metronidazole following intravenous metronidazole (MTZ) and metronidazole phosphate disodium (MNP) in mice was investigated by HPLC. The results showed no significant differences in the metronidazole concentrations of liver, kidney, heart, spleen, fat, brain, lung, stomach, jejunum, skeletal muscle, ovary, testis and epididymis (P greater than 0.05). It can be concluded that using MNP as a water-soluble substitute for MTZ should not influence the distribution of metronidazole in mice.


Jun 17, 1976·The New England Journal of Medicine·R UrtasunC Fryer
May 1, 1977·The Journal of Antimicrobial Chemotherapy·F J Roe
Jan 1, 1978·The Journal of Antimicrobial Chemotherapy·J De LouvoisR Hurley
Apr 1, 1982·Journal of Pharmaceutical Sciences·M J ChoD J Houser

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