A comparison of microbial growth in alfaxalone, propofol and thiopental

The Journal of Small Animal Practice
F A StrachanR E Clutton

Abstract

To compare the growth of Staphylococcus aureus and Escherichia coli in alfaxalone with that in propofol and thiopental and to evaluate contaminant microbial growth in these agents under two different conditions of storage and handling. Known quanta of S aureus and E coli were inoculated into separate 5 ml samples of propofol, thiopental and alfaxalone. Quantitative bacterial analysis was performed at intervals over a 14 day period. Commercial preparations of propofol, thiopental and alfaxalone were stored and handled using "dirty" or "clean" techniques. Microbial quantification and identification was performed over a 14 day period. S aureus and E coli grew rapidly in propofol after six hours. Both bacteria were killed by thiopental. S aureus numbers slowly declined in alfaxalone; E coli growth was rapid after 24 hours. In "dirty" and "clean" groups of intravenous anaesthetics, 9.3 and 7.4 per cent of samples, respectively, were positive for microbial growth; none were considered to represent colonisation of bottles. Alfaxalone supports growth of some microorganisms but less readily than propofol. Bacterial colonisation of intravenous anaesthetic bottles is uncommon, but contamination as syringes are prepared for injection occur...Continue Reading

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Citations

Jan 24, 2014·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Carrie A Schroeder, Rebecca A Johnson
Oct 30, 2015·The Journal of Small Animal Practice·A BellC Devine
Nov 19, 2013·Veterinary Ophthalmology·Michelle M M HasiukDaniel S J Pang
Jan 15, 2015·The Veterinary Journal·Leon N WarneSébastien H Bauquier
Mar 1, 2012·Journal of Feline Medicine and Surgery·Polly M TaylorElizabeth Cozzi
Jun 27, 2018·American Journal of Veterinary Research·Michelle C WhiteheadTara M Harrison

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