A comparison of microstructural maturational changes of the corpus callosum in preterm and full-term children: a diffusion tensor imaging study.

Neuroradiology
Hae Min JoSu Min Son

Abstract

Preterm children with thinning of the corpus callosum (CC) frequently achieve poor neurodevelopmental outcomes despite the absence of a definite brain lesion. Here, the authors compared the microstructural characteristics of the CC in preterm and full-term children using diffusion tensor imaging (DTI). Twenty-two preterm children with no definite focal lesion but with thinning of the CC by conventional magnetic resonance imaging and 23 age-matched full-term children were investigated by DTI. CCs were subdivided into genu, rostral body, body, isthmus, and splenium, and voxel counts (VC), fractional anisotropies (FA), and apparent diffusion coefficients (ADC) were measured in each subdivision. Eleven preterm and 11 age-matched full-term subjects underwent follow-up scanning and interval changes in these parameters for each subdivision were compared. VC and FA were significantly lower in the preterm group than in the full-term group, particularly in the isthmus. Furthermore, incremental changes in VC and FA were significantly smaller in the preterm group. Differences in maturation between the two groups were more pronounced with age in all subdivisions except the splenium. At all ages, noticeable FA differences between the two gro...Continue Reading

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Aug 15, 2013·Neuroradiology·Anand S PanditSerena J Counsell
Oct 1, 2011·Topics in Magnetic Resonance Imaging : TMRI·Fernanda Cristina Rueda-LopesEmerson Leandro Gasparetto
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