Jan 1, 1993

A comparison of midazolam, diazepam, and placebo as oral anesthetic premedicants in younger children

Journal of Clinical Anesthesia
T R Vetter


To validate the superiority of higher-dose oral midazolam as an anesthetic premedicant in children 6 years of age and younger, to determine whether less expensive diazepam is a viable alternative oral premedicant in this age-group, and to assess the preoperative oxygenation effects of both benzodiazepines. A prospective, randomized, double-blind study. Outpatient surgery department and operating room (OR) of a freestanding children's hospital. Seventy-five ASA physical status I and II outpatients 1 to 6 years of age. Patients were randomized to receive either midazolam 0.6 mg/kg, diazepam 0.3 mg/kg, or a placebo orally in a timely manner prior to surgery. Each child's subsequent reaction to separation from his or her parents in the presurgical holding area was scored on a three-point behavioral scale. Once in the OR, an initial room air oxygen saturation by pulse oximeter (SpO2) was obtained. Each child's initial acceptance of the anesthetic induction mask was then scored on a four-point scale. No significant differences in parental separation scores, initial room air SpO2, or postanesthesia care unit admission time were observed among the three study groups. However, both midazolam and diazepam were observed to be superior to ...Continue Reading

Mentioned in this Paper

Separation Anxiety Disorder of Childhood
Psychosexual Disorders
Child Behavior
Insufflation Anesthesia
Anesthesia Recovery Period
Preanesthetic Medication

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