A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?

Molecular Neurobiology
Gerwyn MorrisB K Puri

Abstract

There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis). Systemic inflammation may well be a major element explaining such findings. Inter-patient and inter-illness variations in neuroimaging findings may arise at least in part from regional genetic, epigenetic and environmental variations in the functions of microglia and astrocytes. Regional differences in neuronal resistance to oxidative and inflammatory insults and in the performance of antioxidant defences in the central nervous system may also play a role. Importantly, replicated experimental findings suggest that the use of high-resolution SPECT imaging may have the capacity to differentiate patients afforded a diagnosis of CFS from those with a diagnosis of depression. Further research involving this form of neuroimaging appears warranted in an attempt to overcome the problem of aetiologically heterogeneous cohorts which probably explain conflicting findings produced by investigative teams active in this field. However, the ionisin...Continue Reading

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Citations

Sep 21, 2018·The Australian and New Zealand Journal of Psychiatry·Gerwyn MorrisMichael Berk
Feb 14, 2019·Metabolic Brain Disease·Gerwyn MorrisBasant K Puri
Apr 6, 2020·The Medical Journal of Australia·Carolina X Sandler, Andrew R Lloyd
Jul 14, 2020·Frontiers in Cellular Neuroscience·Antonio BrunoGeorgia Mandolesi
Sep 12, 2019·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gerwyn MorrisMichael Berk
Sep 24, 2019·Neuroscience and Biobehavioral Reviews·Gerwyn MorrisMichael Berk
Apr 8, 2019·Multiple Sclerosis and Related Disorders·Patricia StefancinTimothy Q Duong
Jun 8, 2021·Frontiers in Immunology·Eleni StamoulaGeorgios Papazisis

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Methods Mentioned

BETA
imaging techniques
imaging technique
cognitive-behavioural therapy
histone acetylation
acetylation

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TBSS

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