A comparison of online and offline measurement of exhaled breath for diabetes pre-screening by graphene-based sensor; from powder processing to clinical monitoring prototype

Journal of Breath Research
Ramji Kalidoss, Snekhalatha Umapathy

Abstract

Several breath analysis studies have suggested a correlation between blood glucose (BG) levels and breath acetone, indicating acetone as a primary biomarker in exhaled breath for diabetes diagnosis. Herein, we have (i) fabricated and validated graphene-based chemi-resistive sensors for selective and sensitive detection of acetone, (ii) performed offline breath analysis by a static gas sensing set-up to acquire olfactory signals, and (iii) developed an LED-based portable on/off binary e-nose system for pre-screening diabetes through online analysis. The fabricated sensors showed selective detection for acetone with high sensitivity (5.66 for 1 ppm acetone vapor) and fast response and recovery times (10 s and 12 s) at low concentrations. The sensor responses of end tidal fractional breath (collected in Tedlar bags) in the fasting and postprandial conditions were compared with BG levels and glycated hemoglobin (HbA1c) levels taken at the same time in 30 volunteers (13 healthy and 17 diabetic subjects). The mean sensor responses of the diabetic subjects as obtained by offline analysis were 1.1 times higher than those of the healthy subjects. The optimal regression equation framed with the significant correlating variables for HbA1c...Continue Reading

References

Jan 1, 1986·International Archives of Occupational and Environmental Health·V Fiserova-Bergerova, M L Diaz
Feb 5, 2004·Annals of Biomedical Engineering·Joseph C AndersonMichael P Hlastala
Nov 5, 2005·Archives of Environmental Health·William S LinnHenry Gong
May 2, 2007·Physiological Measurement·M M L SteeghsF J M Harren
Oct 23, 2008·Journal of Exposure Science & Environmental Epidemiology·William S LinnFrank D Gilliland
Jul 15, 2009·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ikuo UetaKiyokatsu Jinno
Oct 8, 2009·Nature Nanotechnology·Gang PengHossam Haick
Jun 1, 2009·Journal of Breath Research·J KingA Amann
Apr 7, 2011·American Journal of Physiology. Endocrinology and Metabolism·Timothy D C MinhPietro R Galassetti
Jun 1, 2011·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Todor A Popov
Jul 5, 2011·Physiological Measurement·Patrik SpanělDavid Smith
Aug 11, 2011·Journal of Breath Research·Marco Righettoni, Antonio Tricoli
Sep 8, 2011·Journal of Breath Research·P GoumaS Stanacevic
Nov 11, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Peter J MazzoneMadhu Sasidhar
Mar 1, 2012·Physiological Measurement·Julian KingBirgit Högl
Mar 14, 2012·Diabetes Research and Clinical Practice·Timothy Do Chau MinhPietro Renato Galassetti
Aug 10, 2013·Accounts of Chemical Research·Gady Konvalina, Hossam Haick
Aug 21, 2013·Journal of Breath Research·Zhennan Wang, Chuji Wang
Dec 7, 2013·Chemical Society Reviews·Hossam HaickAnton Amann
Feb 11, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ikuo UetaYoshihiro Saito
Apr 1, 2014·Journal of Breath Research·Ulrike Tisch, Hossam Haick
Dec 17, 2014·Analytical Chemistry·Adonis Reyes-ReyesNandini Bhattacharya
Jan 13, 2015·Analytical and Bioanalytical Chemistry·Meixiu SunChuji Wang
Mar 10, 2015·Journal of Breath Research·J ObermeierW Miekisch
May 23, 2016·Journal of Environmental Radioactivity·Xue ZouYannan Chu
Jun 13, 2017·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·B Grabowska-PolanowskaI Śliwka
Sep 6, 2017·Journal of Breath Research·M Metsälä
Mar 24, 2018·Diabetes Care·UNKNOWN American Diabetes Association
Apr 22, 2018·Diabetes Care·Matthew C Riddle, William H Herman

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Diabetes

This feed focuses on the latest research on biomarkers used for monitoring disease progression in diabetes.

© 2022 Meta ULC. All rights reserved