A comparison of opioid solutions for patient-controlled epidural analgesia

Anaesthesia
A J SmithM Harmer

Abstract

Sixty patients took part in a randomised, double-blind study to compare the analgesic and side effects of three opioid-containing solutions for patient-controlled epidural analgesia following abdominal surgery. Patients in group 1 received a solution containing bupivacaine 0.125% with fentanyl 10 micrograms.ml-1, group 2 bupivacaine 0.125% with diamorphine 125 micrograms.ml-1, group 3 pethidine 2.5 mg.ml-1. All groups received 4 ml.h-1 background infusion and 3 ml boluses every 20 min if necessary. There were no significant differences between the groups in visual analogue scale pain scores (p = 0.537) or volumes of solution used at 24 h (p = 0.351) or 48 h (p = 0.105). Motor block was significantly higher in group 2 (p < 0.004) and pruritus occurred significantly less in group 3 (p < 0.05). We conclude that these three solutions produce equivalent analgesia but that pethidine 2.5 mg.ml-1 may be associated with fewer side effects.

References

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Citations

Feb 16, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K S KhawL A Critchley
Nov 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory L BrysonMaan Kattan
Aug 10, 2000·Anesthesiology Clinics of North America·J C Crews
Aug 24, 2004·International Journal of Obstetric Anesthesia·J L Plummer, P Brownridge
Jun 27, 2003·Journal of Cardiothoracic and Vascular Anesthesia·Ignacio GaruttiJose M Perez-Peña
Apr 8, 1999·Anaesthesia·J A Gedney, E H Liu
Dec 3, 1998·Acta Anaesthesiologica Scandinavica·I RundshagenJ Schulte am Esch
Jun 10, 1998·Anaesthesia and Intensive Care·W D Ngan Kee

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