A comparison of outcomes associated with carotid artery stent placement performed within and outside clinical trials in the United States

Journal of Vascular Surgery
Adnan I QureshiM Fareed K Suri

Abstract

A discrepancy between characteristics of patients treated with carotid angioplasty and stent placement (CAS) within and outside clinical trials, particularly characteristics with direct impact on clinical outcome, may limit generalization of clinical trial results. The objective of this study was to identify differences in demographic and clinical characteristics and outcomes related to CAS in patients treated within clinical trials and those treated outside clinical trials in a large national cohort. We determined the frequency of CAS performed within and outside clinical trials and associated in-hospital outcomes using data from the Nationwide Inpatient Survey data files from 2005 to 2009. All the in-hospital outcomes were analyzed after adjusting for potential confounders using multivariate analysis. Of the 81,638 patients who underwent CAS, 16,078 (19.6%) underwent the procedure as part of a clinical trial. The mean age of the patients was significantly lower in patients treated with CAS as part of a clinical trial than those treated with CAS outside a clinical trial. The proportion of women and nonwhites was lower among patients treated with CAS as part of a clinical trial. The in-hospital mortality was two-fold higher amo...Continue Reading

References

May 2, 1998·JAMA : the Journal of the American Medical Association·D E WennbergE S Fisher
Sep 20, 2000·Neurology·S ChaturvediA Murugappan
Oct 1, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Michael H WholeyMark H Wholey
Jan 28, 2004·Neurosurgery·Adnan I QureshiUNKNOWN North American Trial of Unruptured and Ruptured Aneurysms Planning Committee
May 4, 2004·Journal of the American College of Cardiology·William A Gray
Jun 16, 2005·Circulation·Harlan M KrumholzUNKNOWN National Heart, Lung, and Blood Institute working group
Jun 18, 2005·Stroke; a Journal of Cerebral Circulation·Mark J AlbertsUNKNOWN Brain Attack Coalition
Aug 8, 2006·Journal of Vascular Surgery·William A GrayUNKNOWN ARCHeR Trial Collaborators
May 26, 2007·Stroke; a Journal of Cerebral Circulation·Adnan I QureshiWayne H Giles
Oct 17, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Douglas MassopUNKNOWN SAPPHIRE Worldwide Investigators
Jul 25, 2009·Journal of Vascular Surgery·Peter W GroeneveldFeifei Yang
Mar 2, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·L Nelson HopkinsThomas G Brott
Apr 30, 2010·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Alberto MaudAdnan I Qureshi
May 28, 2010·The New England Journal of Medicine·Thomas G BrottUNKNOWN CREST Investigators

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Citations

May 25, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Saqib A ChaudhryAdnan I Qureshi
Aug 20, 2015·Circulation. Cardiovascular Interventions·Fenton H McCarthyNimesh D Desai
Aug 15, 2014·Circulation. Cardiovascular Interventions·Luke K KimDmitriy N Feldman
Oct 19, 2013·Stroke; a Journal of Cerebral Circulation·Farhan SiddiqAdnan I Qureshi
May 2, 2013·Stroke; a Journal of Cerebral Circulation·Adnan I QureshiM Fareed K Suri
Oct 28, 2019·Neurology·Emmanuel O AkanoSeemant Chaturvedi
Jun 21, 2014·Expert Review of Cardiovascular Therapy·Kosmas I ParaskevasFrank J Veith

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