A comparison of oxidative stress in smokers and non-smokers: an in vivo human quantitative study of n-3 lipid peroxidation.

BMC Psychiatry
Basant K PuriBrian M Ross

Abstract

Cigarette smoking is believed to cause oxidative stress by several mechanisms, including direct damage by radical species and the inflammatory response induced by smoking, and would therefore be expected to cause increased lipid peroxidation. The aim was to carry out the first study of the relationship of smoking in humans to the level of n-3 lipid peroxidation indexed by the level of ethane in exhaled breath. Samples of alveolar air were obtained from 11 smokers and 18 non-smokers. The air samples were analyzed for ethane using mass spectrometry. The two groups of subjects were matched with respect to age and gender. The mean cumulative smoking status of the smokers was 11.8 (standard error 2.5) pack-years. The mean level of ethane in the alveolar breath of the group of smokers (2.53 (0.55) ppb) was not significantly different from that of the group of non-smokers (2.59 (0.29) ppb; p = 0.92). With all 29 subjects included, the Spearman rank correlation coefficient between ethane levels and cumulative smoking status was -0.11 (p = 0.58), while an analysis including only the smokers yielded a corresponding correlation coefficient of 0.11 (p = 0.75). Our results show no evidence that cigarette smoking is related to increased n-3 ...Continue Reading

References

Jul 4, 2006·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Richard S Bruno, Maret G Traber
Mar 6, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jens Lykkesfeldt
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Basant K PuriIan H Treasaden

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Citations

Nov 28, 2012·The Annals of Occupational Hygiene·Sindre Rabben SvedahlBjørn Hilt
May 9, 2008·BMC Psychiatry·Basant K Puri
Jan 10, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ramin MiriOmidreza Firuzi
Oct 11, 2012·Medical Hypotheses·Juçara Xavier Zaparoli, José Carlos Fernandes Galduróz
Sep 18, 2016·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H J MurffW Zheng
Mar 26, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Shabarinath NambiarYuben Moodley
Jun 6, 2020·Critical Reviews in Toxicology·Stéphanie AlkoussaPerrine J Martin
Jan 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Justyna SzostakJulia Hoeng
Apr 17, 2021·BMC Cardiovascular Disorders·Zahra JalaliAli Esmaeili Nadimi
Dec 29, 2016·Open Access Macedonian Journal of Medical Sciences·Gordana KamcevaElisaveta Stikova

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