A comparison of pharmacoepidemiological study designs in medication use and traffic safety research.

European Journal of Epidemiology
Silvia RaveraLolkje T W de Jong-van den Berg

Abstract

In order to explore how the choice of different study designs could influence the risk estimates, a case-crossover and case-time-control study were carried out and their outcomes were compared with those of a traditional case-control study design that evaluated the association between the exposure to psychotropic medications and the risk of having a motor vehicle accident (MVA). A record-linkage database availing data for 3,786 cases and 18,089 controls during the period 2000-2007 was used. The study designs (i.e., case-crossover and case-time-control) were derived from published literature, and the following psychotropic medicines were examined: antipsychotics, anxiolytics, hypnotics and sedatives, and antidepressants, stratified in the two groups selective serotonin reuptake inhibitors (SSRIs) and other antidepressants. Moreover, in order to further investigate the effects of frequency of psychoactive medication exposure on the outcomes of the case-crossover analysis, the data were also stratified by the number of defined daily doses (DDDs) and days of medication use in the 12 months before the motor vehicle accident. Three-thousand seven-hundred fifty-two cases were included in this second part of the case-crossover analysis...Continue Reading

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Apr 20, 2011·British Journal of Clinical Pharmacology·Silvia RaveraLolkje T W de Jong-van den Berg

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Citations

Nov 22, 2013·European Journal of Epidemiology·Albert HofmanMeike W Vernooij
Oct 24, 2013·British Journal of Clinical Pharmacology·Ludivine OrriolsSamy Suissa
Oct 19, 2013·Pharmacoepidemiology and Drug Safety·Marta AvalosUNKNOWN CESIR research group
Aug 15, 2018·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mohammad BakhriansyahHanno L Tan
Apr 10, 2021·Fundamental & Clinical Pharmacology·Eduardo Gutiérrez-AbejónFrancisco Javier Álvarez

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