A comparison of ProOsteon, DBX, and collagraft in a rabbit model

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
John A LeupoldLangdon A Hartsock

Abstract

Many bone graft substitutes (BGSs) have been developed and are commercially available. These products differ in the tailoring of their properties, including size, form, osteoconductivity, osteoinductivity, and resorption kinetics. Differential enhancement of these properties may optimize the performance of these materials for varying applications. BGSs offer an opportunity to lessen morbidity of harvesting and use of autogenous and/or allograft bone. The purpose of this study is to quantitatively compare the magnitude of bony ingrowth and biodegradation of different commercially available BGS materials in a rabbit femoral defect model. BGSs from each of three classes (ceramic (ProOsteon), demineralized bone matrix (DBX), and composite (Collagraft)) were implanted in cylindrical defects in bilateral femoral condyles of 12 adult New Zealand White rabbits. Each of the three BGS materials and the empty controls were compared. The specimens were harvested at 3 months postimplantation for radiographic and histologic evaluation. Histomorphometry yielded resorption of graft material remaining in the index defect. Magnitude of bony ingrowth was assessed based on an 8-bit 256 densitometry model. Histomorphometric analysis of the data dem...Continue Reading

References

Jan 1, 1990·The Journal of Craniofacial Surgery·J O Hollinger, J C Kleinschmidt
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K Shimazaki, V Mooney
Mar 1, 1987·Journal of Clinical Periodontology·L BlomlöfL Hammarström
Jan 1, 1989·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·S G HoppJ A Gilbert
Jan 1, 1987·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D C MooreD Manske
Jan 1, 1969·Journal of Ultrastructure Research·A R Spurr
Jan 1, 1995·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·R J FriedmanR A Draughn
Aug 27, 1999·The Journal of Bone and Joint Surgery. British Volume·S LouisiaH Petite
Sep 3, 1999·The Orthopedic Clinics of North America·T BoyceN Scarborough
Sep 3, 1999·The Orthopedic Clinics of North America·Y Behairy, M Jasty
Nov 5, 1999·Clinical Orthopaedics and Related Research·E BehraveshA G Mikos
Jan 1, 1995·The Journal of the American Academy of Orthopaedic Surgeons·A R GazdagR A Forster
Jul 6, 2000·The Orthopedic Clinics of North America·S N KhanJ M Lane
Nov 20, 2001·The Journal of Bone and Joint Surgery. American Volume·A S GreenwaldUNKNOWN American Academy of Orthopaedic Surgeons. The Committee on Biological Implants
Mar 12, 2002·The Journal of Bone and Joint Surgery. American Volume·Christopher G Finkemeier

❮ Previous
Next ❯

Citations

Aug 7, 2010·Acta Biomaterialia·Johan Van der StokPeter Patka
Sep 26, 2009·Clinics in Podiatric Medicine and Surgery·Emily A Cook, Jeremy J Cook
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Rubaiya Yunus BashaMukesh Doble
Apr 15, 2011·Clinical Oral Implants Research·Efstathia TsetsenekouGeorg Watzek
Jan 8, 2016·Tissue Engineering. Part a·Jennifer RobinsonElizabeth Cosgriff-Hernandez
Feb 13, 2009·Journal of Biomedical Materials Research. Part a·George J DiasRobert J Kelly
Jun 1, 2010·Advanced Materials·Pamela HabibovicJake E Barralet
May 28, 2014·Clinical Oral Implants Research·José Luis Calvo-GuiradoGeorgios E Romanos
Sep 8, 2010·Journal of Biomaterials Applications·Christine S LewisRonald R Cobb
Jun 23, 2010·Journal of Biomaterials Applications·Steven T MooreRonald R Cobb
Mar 29, 2014·Journal of Veterinary Science·Jong Min KimSeok Hwa Choi
Nov 1, 2011·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·P J WalshF J Buchanan
Oct 2, 2007·Clinical Orthopaedics and Related Research·Emre A TominJoseph M Lane

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.