PMID: 9188116Jan 1, 1997Paper

A comparison of propofol and other sedative use in paediatric intensive care in the United Kingdom

Paediatric Anaesthesia
M L Pepperman, D Macrae

Abstract

The retrospective study was designed to examine the safety of propofol against other sedative agents when used by infusion for the sedation of children requiring mechanical ventilation. One-hundred-and-ninety-eight patients were recruited. One-hundred-and-six received propofol and 92 received other sedative agents for durations of 30 min to 156 days and 13 min to 11 days respectively. The mean infusion rate of propofol was 3.39 mg.kg-1.h-1. Sixty-one of the 92 patients in the nonpropofol group received midazolam at a mean infusion rate of 0.4 mg.kg-1.h-1. Forty-one patients developed clinical metabolic acidosis with five falling into the pathological range as defined. Seventeen received propofol and 24 another sedative agent. Seventy-eight percent of patients that became acidotic were under the age of three. No patients who became acidotic was noted to have lipaemic serum. Three of four patients were recorded as having lipaemic serum received propofol, however two of these patients along with the patient that received midazolam also received Intralipid. Overall mortality was similar in both sedation groups with 27 deaths being recorded. Thirteen patients received propofol. Five nonfatal adverse events occurred, three in patient...Continue Reading

Citations

Dec 23, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·K YamamotoT Kobayashi
Sep 28, 2004·Der Anaesthesist·J Motsch, J Roggenbach
Jan 16, 2014·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Angshuman Dutta, Sachin Shouche
Oct 24, 2002·British Journal of Clinical Pharmacology·Catherijne A J KnibbeMeindert Danhof
Dec 4, 1998·Paediatric Anaesthesia·R J Bray
Feb 14, 2016·Anaesthesia·Y SasabuchiK Fushimi
Dec 12, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·I ConstantN Louvet
Jul 11, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·P Nolent, V Laudenbach
May 22, 2004·Paediatric Anaesthesia·Davinia E WithingtonTareq Al Ayed
May 18, 2010·Paediatric Anaesthesia·Isabelle Constant, Agnes Rigouzzo
Jun 20, 2001·Pediatric Clinics of North America·D M Polaner
Nov 12, 2003·The Journal of Burn Care & Rehabilitation·Robert L SheridanLesa Breault
Aug 31, 2000·Critical Care Medicine·N D PerrierM J Murray
Aug 4, 2010·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Marsha L Ellett
Jul 11, 2006·Current Opinion in Anaesthesiology·Axel FudickarPeter H Tonner
Aug 30, 2006·European Journal of Anaesthesiology·K AhlenA H Pulsford
Jun 23, 2007·Anesthesiology·Frank Wappler, Jeannette Horn
Nov 20, 2013·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Hiromi KoriyamaUNKNOWN Sedation Withdrawal and Analgesia Team
Oct 5, 2006·Current Opinion in Anaesthesiology·Robin J Bray
Oct 5, 2006·Current Opinion in Anaesthesiology·M Chollet-Rivier, R L Chioléro
Feb 4, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Mary E HartmanScott R Schulman
Nov 15, 2011·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Markus A KruessellUwe Trieschmann
May 26, 2001·Anesthesiology·A E BadrJ H Eichhorn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.