A comparison of protocols for simulating hemorrhage in humans: step versus ramp lower body negative pressure.

Journal of Applied Physiology
Alexander J RosenbergCaroline A Rickards

Abstract

Lower body negative pressure (LBNP) elicits central hypovolemia, and it has been used to simulate the cardiovascular and cerebrovascular responses to hemorrhage in humans. LBNP protocols commonly use progressive stepwise reductions in chamber pressure for specific time periods. However, continuous ramp LBNP protocols have also been utilized to simulate the continuous nature of most bleeding injuries. The aim of this study was to compare tolerance and hemodynamic responses between these two LBNP profiles. Healthy human subjects (N = 19; age, 27 ± 4 y; 7 female/12 male) completed a 1) step LBNP protocol (5-min steps) and 2) continuous ramp LBNP protocol (3 mmHg/min), both to presyncope. Heart rate (HR), mean arterial pressure (MAP), stroke volume (SV), middle and posterior cerebral artery velocity (MCAv and PCAv), cerebral oxygen saturation (ScO2), and end-tidal CO2 (etCO2) were measured. LBNP tolerance, via the cumulative stress index (CSI, summation of chamber pressure × time at each pressure), and hemodynamic responses were compared between the two protocols. The CSI (step: 911 ± 97 mmHg/min vs. ramp: 823 ± 83 mmHg/min; P = 0.12) and the magnitude of central hypovolemia (%Δ SV, step: -54.6% ± 2.6% vs. ramp: -52.1% ± 2.8%; P = ...Continue Reading

References

Jun 1, 1992·Journal of Neurosurgery·C A GillerD J Borchers
Mar 1, 1991·Annals of Neurology·W J Powers
Jul 1, 1974·Physiological Reviews·R A WolthuisA E Nicogossian
Jun 1, 1970·The American Journal of Cardiology·C Potanin, B Sinclair-Smith
Oct 1, 1965·The American Journal of Cardiology·P M Stevens, L E Lamb
Mar 27, 2001·Muscle & Nerve·A R PatelT C Chelimsky
Jun 22, 2001·European Journal of Applied Physiology·R HowdenI L Swaine
Mar 16, 2004·Journal of Applied Physiology·William H CookeVictor A Convertino
Mar 17, 2004·European Journal of Applied Physiology·Kichang LeeWarren D Franke
Jun 9, 2004·Autonomic Neuroscience : Basic & Clinical·Victor A ConvertinoWilliam H Cooke
Mar 25, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Douglas Curran-Everett, Dale J Benos
Jul 30, 2011·Journal of Applied Physiology·Caroline A RickardsVictor A Convertino
Sep 17, 2011·Journal of Applied Physiology·Andrew W SubudhiRobert C Roach
Sep 24, 2011·Journal of Applied Physiology·William H CookePaul Cox
Dec 21, 2013·Journal of Applied Physiology·Carmen Hinojosa-LabordeVictor A Convertino
Jul 12, 2014·Journal of Applied Physiology·Nicole S CoverdaleJ Kevin Shoemaker
Sep 14, 2014·The Journal of Physiology·Nia C S LewisPhilip N Ainslie
Jul 25, 2015·Journal of Anesthesia History·George J Crystal, M Ramez Salem
Oct 2, 2015·Comprehensive Physiology·Caroline A Rickards
Nov 27, 2015·Physiological Reports·Victoria L Kay, Caroline A Rickards
Dec 18, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Victoria L Kay, Caroline A Rickards
May 26, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Victoria L KayCaroline A Rickards
Mar 8, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Baraa K Al-KhazrajiJ Kevin Shoemaker
Dec 13, 2018·Physiological Reviews·Nandu GoswamiVictor A Convertino
May 16, 2020·Advances in Physiology Education·Douglas Curran-Everett

❮ Previous
Next ❯

Methods Mentioned

BETA
pregnancy test
infrared spectroscopy

Software Mentioned

WinCPRS
JMP Pro

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Aviation, Space, and Environmental Medicine
Nandu GoswamiHelmut Hinghofer-Szalkay
Aviation, Space, and Environmental Medicine
R W Gotshall
Aviation, Space, and Environmental Medicine
Jonny HisdalLars Walløe
© 2021 Meta ULC. All rights reserved