PMID: 9444495Jan 1, 1997Paper

A comparison of qEEG and HMPAO-SPECT in relation to the clinical severity of Alzheimer's disease

European Archives of Psychiatry and Clinical Neuroscience
T J MüllerW K Strik

Abstract

Electroencephalographical studies have disclosed correlations between topographical features of Fast Fourier Transformation maps and the severity of Alzheimer's disease (DAT). The object of the present study was to explore the relations of HMPAO-SPECT and quantitative EEG (qEEG) with the severity of dementia. Twenty-three patients were included in the study. Spectral and topographical EEG parameters were compared with global and regional cerebral blood flow, and with psychometric measures of clinical severity. None of the regions of interest of the SPECT scans were significantly correlated with clinical severity. Low values in delta- and theta bands, however, were related to high scores on the Mini-Mental-State examination (P < 0.01), whereas the Syndrome-Kurz test correlated inversely with the power values in the alpha and beta band. The global decrease in cerebral blood flow (CBF) was associated with a shift on the topographical alpha-centroids in the posterior direction (P < 0.01). In previous studies correlations between CBF and clinical severity were weak, indicating a high interindividual variance, or interactions with concomitant vascular lesions. Whereas SPECT is a well-established tool for the diagnosis of dementia, th...Continue Reading

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Citations

Dec 21, 2013·Journal of Neural Transmission·Izabela SokolowskaAlisa G Woods
Apr 26, 2006·Best Practice & Research. Clinical Anaesthesiology·Andreas SpiegelMaurizio Renna
Feb 9, 2006·Brain Research Bulletin·Claudio BabiloniPaolo M Rossini
May 22, 2001·Clinical EEG (electroencephalography)·J Bosch-BayardN Trujillo-Barreto
Oct 27, 2005·International Journal of Geriatric Psychiatry·Dimitrios AdamisAdrian Treloar
Feb 7, 2012·Journal of Cellular and Molecular Medicine·Alisa G WoodsCostel C Darie
Nov 10, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Norbert SchuffMichael W Weiner
Apr 12, 2016·Frontiers in Pharmacology·Lieven D DeclercqGuy Bormans
Sep 19, 2021·Medical & Biological Engineering & Computing·Matous CejnekIvo Bukovsky

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