A comparison of receptive-field and tracer-coupling size of amacrine and ganglion cells in the rabbit retina

Visual Neuroscience
Stewart A Bloomfield, D Xin

Abstract

Recent studies have shown that amacrine and ganglion cells in the mammalian retina are extensively coupled as revealed by the intercellular movement of the biotinylated tracers biocytin and Neurobiotin. These demonstrations of tracer coupling suggest that electrical networks formed by proximal neurons (i.e. amacrine and ganglion cells) may underlie the lateral propagation of signals across the inner retina. We studied this question by comparing the receptive-field size, dendritic-field size, and extent of tracer coupling of amacrine and ganglion cells in the dark-adapted, superfused, isolated retina eyecup of the rabbit. Our results indicate that while the center-receptive fields of proximal neurons are approximately 15% larger than their corresponding dendritic diameters, this slight difference can be explained by factors other than electrical coupling such as tissue shrinkage associated with histological processing. However, the extent of tracer coupling of amacrine and ganglion cells was, on average, about twice the size of the corresponding receptive fields. Thus, the receptive field of an individual proximal neuron matched far more closely to its dendritic diameter than to the size of the tracer-coupled network of cells to...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M A FreedP Sterling
Jan 1, 1992·Journal of Neuroscience Methods·M Pu, D M Berson
Feb 15, 1991·The Journal of Comparative Neurology·S L Mills, S C Massey
Jul 17, 1990·Neuroscience Letters·K Negishi, T Teranishi
May 15, 1990·The Journal of Comparative Neurology·E StrettoiE Raviola
Sep 1, 1987·The Journal of Comparative Neurology·L PeichlB B Boycott
Jun 22, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D I Vaney
Feb 1, 1989·The Journal of Comparative Neurology·F R AmthorC W Oyster
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E Raviola, R F Dacheux
Sep 1, 1985·Journal of Neurophysiology·R Nelson, H Kolb
Oct 4, 1974·Science·H Kolb, E V Famiglietti
Sep 1, 1971·Journal of Neurophysiology·K I Naka, P W Nye
Jan 1, 1965·Cold Spring Harbor Symposia on Quantitative Biology·T Tomita
Feb 1, 1971·The Journal of Physiology·A Kaneko
Sep 1, 1967·The Journal of Physiology·K I Naka, W A Rushton
Jul 1, 1982·The Journal of Comparative Neurology·S A Bloomfield, R F Miller
Feb 1, 1983·Journal of Neurophysiology·D N Mastronarde
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M PiccolinoH M Gerschenfeld
Nov 17, 1995·Science·M MeisterD A Baylor
Mar 1, 1993·The Journal of Comparative Neurology·R NelsonM A Freed
Aug 1, 1995·Microscopy Research and Technique·J E Cook, D L Becker
Nov 1, 1995·The European Journal of Neuroscience·W R Taylor, H Wässle
Jan 1, 1996·Journal of Neurophysiology·B N Peters, R H Masland
Jul 14, 1997·The Journal of Comparative Neurology·D Xin, S A Bloomfield

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Citations

Mar 1, 2005·Visual Neuroscience·Jianguo XiaoDavid Marshak
Nov 30, 2018·Frontiers in Neural Circuits·Robert E MarcBryan William Jones
Feb 18, 1999·The Journal of Comparative Neurology·D Xin, S A Bloomfield
Oct 12, 2007·Journal of Neurophysiology·Alyosha Molnar, Frank Werblin
Sep 24, 2004·The Journal of Comparative Neurology·Edward V Famiglietti
Jul 21, 2007·Visual Neuroscience·W Wade KothmannJohn O'Brien
Jul 2, 2019·Investigative Ophthalmology & Visual Science·Sammy C S LeeUlrike Grünert
May 14, 2020·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Andrew J ZeleBeatrix Feigl
Jun 6, 2009·Nature Reviews. Neuroscience·Stewart A Bloomfield, Béla Völgyi
Dec 4, 2008·The Journal of Comparative Neurology·Béla VölgyiStewart A Bloomfield
Mar 23, 2004·Biochimica Et Biophysica Acta·Sheriar G HormuzdiRoberto Bruzzone

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