PMID: 3755369Jul 9, 1986Paper

A comparison of regional somatostatin and neuropeptide Y distribution in rat striatum and brain

Brain Research
M F BealJ B Martin

Abstract

Somatostatin-like immunoreactivity (SLI) and neuropeptide Y-like immunoreactivity (NPYLI) were detected using specific radioimmunoassays in extracts from rat brain. Since we have previously found a topographic distribution of SLI in rat striatum the distribution of NPYLI was examined in the same regions. NPYLI showed an identical distribution to SLI in rat striatum and levels were significantly correlated (r = 0.93, P less than 0.01). Concentrations of both neuropeptides were consistently highest in ventromedial striatum and nucleus accumbens while they were lowest in dorsolateral striatum. These findings provide further evidence of neurochemical heterogeneity in the striatum. Concentrations of NPYLI and SLI were also significantly correlated in cerebral cortex (r = 0.99, P less than 0.01). Concentrations of NPYLI were generally higher than SLI and showed a similar predilection for limbic system nuclei. The present findings support the concept that somatostatin and neuropeptide Y may be co-localized in both striatal and cortical neurons.

References

Mar 1, 1973·Archives of Biochemistry and Biophysics·P BöhlenS Udenfriend
Apr 28, 1980·Brain Research·C Bennett-ClarkeS A Joseph
Jul 1, 1982·Nature·S R VincentJ Kimmel
Aug 26, 1983·Science·Y S AllenJ M Polak
Nov 14, 1983·Brain Research·M F BealJ B Martin
Dec 1, 1983·Journal of the Neurological Sciences·I N FerrierG P McGregor
Dec 8, 1983·Nature·T E AdrianJ M Polak
Jan 1, 1984·Regulatory Peptides·J M AllenS R Bloom
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto
Aug 31, 1981·Brain Research·M A Rea, J R Simon

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Citations

Jun 1, 1987·Neurochemical Pathology·M F BealJ B Martin
Jan 16, 1989·Brain Research·J VuilletA Nieoullon
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E Obuchowicz, J Turchan
Apr 22, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Henrike HartungStephanie J Cragg
Jan 1, 1990·Fundamental & Clinical Pharmacology·J M DangerH Vaudry
Nov 22, 1994·The Journal of Comparative Neurology·W RushlowB A Flumerfelt
Jan 23, 1995·The Journal of Comparative Neurology·W RushlowC C Naus

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