A comparison of response criteria to evaluate therapeutic response in patients with juvenile idiopathic arthritis treated with methotrexate and/or anti-tumor necrosis factor alpha agents

Arthritis and Rheumatism
A LuratiF Fantini

Abstract

There are no validated criteria to evaluate clinical response in juvenile idiopathic arthritis (JIA). The purpose of this study was to compare 4 sets of criteria (2 from the American College of Rheumatology [ACR] and 2 from the European League Against Rheumatism [EULAR]) for clinical response evaluation in JIA patients treated with methotrexate and/or anti-tumor necrosis factor alpha drugs. Seventy-five patients with JIA were evaluated at baseline and after 6 months of therapy with second-line drugs. Mean age at study onset was 12.8 years (range 2-32.9 years). Diagnoses were systemic JIA (n = 16), rheumatoid factor-positive JIA (n = 5), rheumatoid factor-negative JIA (n = 9), persistent oligoarticular JIA (n = 10), extended oligoarticular JIA (n = 33), and psoriatic arthritis (n = 2). Clinical response was evaluated with the ACR Pediatric 30 criteria and the ACR 20% response criteria (ACR20), and with the EULAR Disease Activity Score (DAS) and 28-joint DAS (DAS28). Patients with EULAR criteria responses of "good" or "moderate" were classified as responders. Responders and nonresponders according to the different criteria were then compared. For patients younger than 16 years, Cohen's kappa varied between 0.51 and 0.72, with a g...Continue Reading

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Citations

Sep 5, 2006·Nature Clinical Practice. Rheumatology·Olcay Y Jones, Daniel J Lovell
Sep 1, 2007·Current Opinion in Rheumatology·Sarah Ringold, Carol A Wallace
Feb 28, 2007·Annals of the Rheumatic Diseases·Rolando CimazPierre Miossec
Jan 8, 2013·BMC Pediatrics·Ilham BouaddiNajia Hajjaj-Hassouni
Apr 3, 2014·BMC Musculoskeletal Disorders·Ilham BouaddiNajia Hajjaj-Hassouni
Mar 28, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·J de Inocencio ArocenaJ García-Consuegra Molina
Sep 13, 2016·Iranian Journal of Pediatrics·Marjan VakiliTayebeh Rahamooz
Dec 3, 2014·Revista brasileira de reumatologia·Renata Campos CapelaClaudia Saad Magalhães

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