A comparison of scar revision with the free electron and carbon dioxide resurfacing lasers

Plastic and Reconstructive Surgery
J S ChenD L Ellis

Abstract

Laser scar revision was studied to measure the effects of targeting extracellular matrix protein versus tissue water on scar revision. We compared the free electron laser used at 7.7 microm (the amide III protein absorption band) to the carbon dioxide (CO2) laser and dermabrasion.Nude mice (n = 40) that had rejected skin grafts on their dorsal surface and developed mature scars were used as a model for scar revision. One-half of each scar was revised with either the free electron laser at 7.7 microm (32 to 38 mJ, nonoverlapping pulses delivered with a computerized adjustable pattern generator at 30 Hz, and two to three passes), a 100-microsec CO2 resurfacing laser (500 mJ, 5.0 Hz, and two to five passes), or dermabrasion. The untreated portion of each scar served as an internal control. Evaluation was by measurement of the clinical size of the scar using photography with quantitative computer image analysis to compare the data and histology to evaluate the quality and depth of the scars. The free electron laser at 7.7 microm was significantly better than the CO2 laser and dermabrasion for scar size reduction (p < 0.046 and p < 0.018). The CO2 laser and a highly skilled dermabrader were not statistically significantly different ...Continue Reading

References

Jan 1, 1988·Lasers in Surgery and Medicine·J T Walsh, T F Deutsch
Jan 1, 1988·Lasers in Surgery and Medicine·J T WalshT F Deutsch
Sep 1, 1996·Seminars in Cutaneous Medicine and Surgery·T S AlsterR G Geronemus
Jan 1, 1996·Lasers in Surgery and Medicine·E S GardnerD L Ellis
Jul 1, 1997·Dermatologic Clinics·T B West
Jul 1, 1997·Dermatologic Clinics·A N Kauvar, R G Geronemus
Jun 1, 1997·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·B KaplanR L Moy
Jun 17, 1998·The Laryngoscope·D S FortuneL Reinisch
Jul 28, 1999·Lasers in Surgery and Medicine·D L EllisL Reinisch
Mar 4, 1988·Science·C A Brau

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Citations

Sep 7, 2007·PLoS Medicine·Shahram AarabiGeoffrey C Gurtner
Oct 1, 2008·Drug Discovery Today·Nick L OcclestonMark W J Ferguson

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