A comparison of serum androgens in pre-eclamptic and normotensive pregnant women during the third trimester of pregnancy

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Fatemeh SharifzadehFarnaz Fatemi

Abstract

To compare the serum androgens level during the third trimester of pregnancy between normotensive and pre-eclamptic women. A case-control study was performed on 64 pregnant women with the gestational age of 28-34 weeks. 32 women were pre-eclamptic (case group), and 32 women were normotensive till term gestation (control group). The serum level of androgens including sex hormone binding globulin (SHBG), total and free testosterone, androstenedione (ADD), and dehydroepiandrosterone sulfate (DHEA-S), were compared between the two groups. The women of the two groups had no statistically significant difference according to age, gestational age, BMI (body mass index), parity and fetal sex. Serum level of SHBG (90.86 ± 9.30 vs. 55.86 ± 8.02 nmol/l, p = 0.02), total testosterone (3.70 ± 0.57 vs. 2.06 ± 0.24 ng/ml, p = 0.01), free testosterone (1.28 ± 0. 17 vs. 0. 74 ± 0.07 pg/ml, p = 0.01), and ADD (2.47 ± 0.10 vs. 2.17 ± 0.10 ng/ml, p = 0.04), was higher in the pre-eclamptic women. However, there was no difference between the two groups for DHEA-S (0.75 ± 0.18 vs. 0.51 ± 0.08 μg/ml, p = 0.19). Serum androgen levels during third trimester of pregnancy are higher in pre-eclamptic women and this may propose an effect of androgens in the ...Continue Reading

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Citations

Mar 20, 2014·Human Reproduction Update·Sofia MakievaJane E Norman
Aug 1, 2015·Molecular Reproduction and Development·Jingjie XuHaibin Kuang
Dec 17, 2014·Reproductive Toxicology·Jeremy Michals SchrawMichele R Forman
Oct 17, 2014·Stress : the International Journal on the Biology of Stress·Tamar WainstockLiat Lerner-Geva
Jun 25, 2013·American Journal of Obstetrics and Gynecology·Satu MiettolaEero Kajantie
May 21, 2016·Frontiers in Physiology·Manuel MaliqueoNicolás Crisosto
Jun 19, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·D JaskolkaC K Kramer
Oct 13, 2016·The Journal of Endocrinology·D S Boeldt, I M Bird
Mar 23, 2017·Endocrine Reviews·Nadia BerkaneNathalie Chabbert-Buffet
Aug 9, 2019·The Journal of Clinical Endocrinology and Metabolism·Angela S KelleyVasantha Padmanabhan
May 13, 2020·Biology of Sex Differences·Zoe A Broere-BrownSarah Schalekamp-Timmermans
Sep 28, 2018·Frontiers in Pharmacology·Waranya ChatuphonprasertIsabella Ellinger
Jan 1, 2014·International Journal of Reproductive Medicine·Joselyn RojasValmore Bermúdez
Oct 21, 2020·Reproductive Biomedicine Online·Ragnheidur ValdimarsdottirInger Sundström Poromaa

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