A comparison of serum inflammatory cytokines according to phenotype in patients with psoriasis

The British Journal of Dermatology
Y B ChoeJ I Youn

Abstract

Plaque-type psoriasis manifests with various morphological phenotypes and different clinical activity over time in the same individual or from one patient to another. Circulating cytokines, especially T-helper (Th) 1- and Th17-related, have been suggested to reflect the inflammatory nature of psoriasis. However, studies regarding cytokine profile according to morphological phenotypes are quite scarce. We sought to analyse the circulating Th1 and Th17 cytokines according to clinical phenotype and investigated the correlation between disease severity [Psoriasis Area and Severity Index (PASI)] and the serum level of inflammatory cytokines. Seventy-one patients with psoriasis were divided into two groups according to clinical phenotype: chronic stable (CS) and eruptive inflammatory (EI). Th1- and Th17-derived cytokines were measured using multiplex cytokine assay. It was noted that interleukin (IL)-1 receptor antagonist and IL-17A were elevated in the EI group compared with the CS group. We also noticed that the PASI is relatively well correlated with serum cytokine level in the CS state but not as well in the EI counterpart. The level of serum inflammatory cytokines differs according to morphological phenotype. Also, the PASI does...Continue Reading

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Citations

Sep 10, 2014·Mediators of Inflammation·Young Ji HwangKyu Joong Ahn
Apr 29, 2015·Journal of Cutaneous Medicine and Surgery·Christina FotiadouDemetris Ioannides
Oct 12, 2018·Scandinavian Journal of Immunology·Silje M SolbergSilke Appel
Jul 10, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·J W LeeM G Lee
Oct 20, 2019·Dermatologic Therapy·Beniamin Oskar GrabarekAnna Michalska-Bańkowska
Aug 13, 2015·Experimental Dermatology·Hong ChengYumin Xia
Feb 9, 2018·Frontiers in Cellular and Infection Microbiology·Tomoko SumitomoShigetada Kawabata
Aug 2, 2017·Annals of Dermatology·Ji Hoon ChunChul Jong Park
Jun 27, 2020·Mediators of Inflammation·Anna Michalak-StomaGrażyna Chodorowska
Jun 7, 2021·The Journal of Investigative Dermatology·Kim KlapanHans-Uwe Simon

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