A comparison of sexual and asexual replication strategies in a simplified model based on the yeast life cycle.

Theory in Biosciences = Theorie in Den Biowissenschaften
Emmanuel Tannenbaum

Abstract

This paper develops simplified mathematical models describing the mutation-selection balance for the asexual and sexual replication pathways in Saccharomyces cerevisiae, or Baker's yeast. The simplified models are based on the single-fitness-peak approximation in quasispecies theory. We assume diploid genomes consisting of two chromosomes, and we assume that each chromosome is functional if and only if its base sequence is identical to some master sequence. The growth and replication of the yeast cells is modeled as a first-order process, with first-order growth rate constants that are determined by whether a given genome consists of zero, one, or two functional chromosomes. In the asexual pathway, we assume that a given diploid cell divides into two diploids. For the sake of generality, our model allows for mitotic recombination and asymmetric chromosome segregation. In the sexual pathway, we assume that a given diploid cell divides into two diploids, each of which then divide into two haploids. The resulting four haploids enter a haploid pool, where they grow and replicate until they meet another haploid with which to fuse. In the sexual pathway, we consider two mating strategies: (1) a selective strategy, where only haploids...Continue Reading

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Citations

Sep 19, 2012·Risk Analysis : an Official Publication of the Society for Risk Analysis·Lawrence V TannenbaumKarl V Miller
Dec 18, 2015·F1000Research·Esmeralda VicedoBurkhard Rost
Dec 8, 2015·Journal of Applied Behavior Analysis·Cindy GevarterGiulio E Lancioni
Oct 30, 2014·American Journal on Intellectual and Developmental Disabilities·Jennifer B GanzJohn L Davis

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