A comparison of sister chromatid exchanges in lymphocytes of anesthesiologists to nonanesthesiologists in the same hospital

Anesthesia and Analgesia
Ahmet ErogluNesrin Erciyes

Abstract

An increased incidence of sister chromatid exchanges (SCEs) in peripheral lymphocytes of operating room personnel exposed to waste anesthetic gases has been reported. We investigated whether the increase of SCEs in anesthesiologists was reversible. Twenty-five anesthesiologists exposed to waste anesthetic gases such as sevoflurane and nitrous oxide were compared with nonexposed internists working in the same hospital. The concentrations of sevoflurane and nitrous oxide in the operating rooms were measured. The incidence of SCE was measured in lymphocytes cultures of anesthesiologists before and after a 2-mo leave from the operating room. These values of SCE were compared with those of nonexposed physicians. Occupational exposure to sevoflurane and nitrous oxide in the operating rooms were above the threshold values. There was a significant difference in SCE values of the anesthesiologists compared with the nonexposed physicians (11.9 +/- 4.4 versus 4.2 +/- 1.1, P < 0.001). After a 2-mo leave from the operating room, the SCE values of the anesthesiologists were significantly lower compared with those taken before the leave (4.8 +/- 1.8 and 11.9 +/- 4.4, respectively, P < 0.001). We conclude that the increase of SCE in anesthesio...Continue Reading

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Citations

Dec 28, 2010·Archives of Environmental & Occupational Health·Seval IzdesAli Esat Karakaya
May 21, 2011·Expert Opinion on Drug Safety·Daniela SchifillitiVincenzo Fodale
Jul 11, 2008·Expert Opinion on Drug Safety·V FodaleLb Santamaria
Apr 1, 2009·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Renee A Smith
Apr 25, 2014·Acta Cirúrgica Brasileira·Ellen Regina da Costa PaesJosé Reinaldo Cerqueira Braz
Jun 29, 2017·Revista brasileira de anestesiologia·Lorena M C LucioLeandro G Braz
Sep 25, 2008·Anesthesiology·Robert D SandersMervyn Maze
Nov 1, 2012·Human & Experimental Toxicology·A A El-EbiaryM M Othman

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