A comparison of sodium bicarbonate infusion versus normal saline infusion and its combination with oral acetazolamide for prevention of contrast-induced nephropathy: a randomized, double-blind trial.

International Urology and Nephrology
Maryam PakfetratParviz Khajehdehi

Abstract

Contrast-induced nephropathy (CIN) is commonly encountered. Because the therapy of choice for prevention of CIN is controversial, in this study we compared the preventive efficacy of bicarbonate (Bi) infusion in dextrose water versus normal saline (NLS) infusion alone or in combination with oral acetazolamide (AZ). In a double-blind and randomized clinical trial, all patients undergoing coronary angiography or percutaneous coronary intervention received NLS (NLS group), its combination with AZ (AZ group) or infusion of Bi (Bi group) before the procedures. RIFLE (risk of renal failure, injury to the kidney, failure of kidney function, loss of kidney function, and end-stage renal disease) criteria were used to define CIN-associated acute kidney injury (AKI). The risk of AKI in CIN was significantly lower in the Bi and AZ groups than in the NLS group (P <or= 0.04). Comparing pre-treatment and post-treatment values in each group the following results were obtained: serum creatinine (Scr) increased and eGFR decreased significantly in the NLS group (P = 0.04) and in all patients (P = 0.001, P = 0.02, respectively). In addition, serum potassium decreased significantly in the Bi and NLS groups (P <or= 0.02). Also, serum Bi increased si...Continue Reading

References

Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Aug 1, 1994·Journal of the American Society of Nephrology : JASN·B J Barrett
Jan 1, 1997·International Urology and Nephrology·A AnaratR Anarat
Jul 21, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R E KatholiW P McCann
May 19, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S Ahmad
Dec 29, 2000·Mayo Clinic Proceedings·A PfluegerF G Knox
Feb 13, 2001·British Journal of Pharmacology·P PickkersP Smits
May 20, 2004·JAMA : the Journal of the American Medical Association·Gregory J MertenThomas P Kennedy
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Rinaldo BellomoUNKNOWN Acute Dialysis Quality Initiative workgroup
Apr 12, 2005·Journal of Pharmacological Sciences·Yoshinori ItohRyozo Oishi
Jul 22, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Simona DetrenisGiorgio Savazzi
Dec 13, 2005·Journal of Interventional Cardiology·Rainer Schräder
Jan 28, 2006·The Journal of Physiology·Luc J TeppemaAlbert Dahan
Feb 28, 2006·American Journal of Hypertension·Yoshio HoritaKouichi Taura
May 26, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Norbert H Lameire
May 26, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·William F Finn
Jun 9, 2006·The New England Journal of Medicine·Lesley A StevensAndrew S Levey
Jun 22, 2006·JAMA : the Journal of the American Medical Association·Neesh PannuUNKNOWN Alberta Kidney Disease Network
May 26, 2007·Journal of Interventional Cardiology·Roxana Mehran
Oct 24, 2007·Revista española de cardiología·Alberto Bouzas-MosqueraAlfonso Castro-Beiras
Jan 8, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin MöckelKai-Uwe Eckardt
Jan 25, 2008·American Heart Journal·Jeremiah R BrownUNKNOWN Northern New England Cardiovascular Disease Study Group

❮ Previous
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Citations

Nov 19, 2009·Intensive Care Medicine·Michael JoannidisUNKNOWN Critical Care Nephrology Working Group of the European Society of Intensive Care Medicine
Aug 27, 2009·International Urology and Nephrology·Rahmi Yilmaz, Yunus Erdem
Jul 6, 2010·International Urology and Nephrology·Jordan L RosenstockMichael F Michelis
Aug 26, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Eric A J HosteJohn A Kellum
Dec 29, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Christian J Wiedermann, Michael Joannidis
Oct 11, 2011·Cardiology in Review·Rahim Kassamali, Domenic A Sica
Jul 14, 2010·Current Opinion in Nephrology and Hypertension·Steven D Weisbord, Paul M Palevsky
Mar 3, 2010·Investigative Radiology·Samuel N HeymanChristian Rosenberger
Jun 5, 2014·BioMed Research International·Michele AndreucciAdis Tasanarong
Sep 10, 2014·BioMed Research International·Michele AndreucciAshour Michael
Dec 20, 2014·TheScientificWorldJournal·Michele AndreucciAshour Michael
Nov 29, 2013·Advances in Medical Sciences·I T JarockaS Dobrzycki
Mar 19, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Paul M PalevskySteven D Weisbord
Jan 25, 2014·BioMed Research International·Antonio PisaniMassimo Sabbatini
Oct 5, 2013·Insights Into Imaging·Remy W F GeenenAart J van der Molen
Jul 26, 2011·Seminars in Nephrology·Steven D Weisbord, Paul M Palevsky
Aug 28, 2010·Hemodialysis International·Maryam PakfetratParviz Khajehdehi
Sep 3, 2013·Interactive Cardiovascular and Thoracic Surgery·Dilan DabarePerbinder Grewal
Jul 11, 2013·Anesthesiology Research and Practice·Véronique BrulottePierre Beaulieu
Apr 18, 2016·Seminars in Nephrology·Steven D Weisbord, Paul M Palevsky
Apr 29, 2015·Singapore Medical Journal·Kheng Song LeowCher Heng Tan
May 15, 2015·Cardiology Research and Practice·Sadegh Ali-Hassan-SayeghAron-Frederik Popov
Sep 3, 2014·BioMed Research International·Horng-Ruey ChuaRinaldo Bellomo
Apr 8, 2018·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Megan A Van Berkel, Jessica L Elefritz
May 11, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Steven D WeisbordPaul M Palevsky
Nov 14, 2017·The New England Journal of Medicine·Steven D WeisbordUNKNOWN PRESERVE Trial Group
Sep 26, 2019·The New England Journal of Medicine·Roxana MehranSteven D Weisbord
Jun 2, 2018·International Journal of Nephrology·D PatschanO Ritter
Sep 26, 2019·The New England Journal of Medicine·Estelle C NijssenUNKNOWN AMACING Investigators

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