PMID: 97703May 31, 1978

A comparison of some pharmacological actions of morphine and delta9-tetrahydrocannabinol in the mouse

A S Bloom, W L Dewey


The effects of morphine and delta9-tetrahydrocannabinol(THC)on the tail-flick reflex, body temperature, and catecholamine synthesis were examined in the mouse in order to compare their effects in a single species and strain under uniform conditions. Naloxone antagonism of THC and cross-tolerance between morphine and THC were also studied. Both morphine and THC produced antinociception, hypothermia, and increased catecholamine synthesis at 30 min after s.c. injection. Morphine produced greater increases in dopamine synthesis and was a more potent antinociceptive agent, while THC produced greater increases in norepinephrine synthesis and was a more potent hypothermic agent. Naloxone pretreatment (1 mg/kg) partially antagonized the hypothermia and increase in catecholamine synthesis produced by THC. There was also cross-tolerance between morphine and THC, but it was asymmetric in that THC-tolerant animals were cross-tolerant to only the hypothermic action of morphine and morphine-tolerant animals cross-tolerant to only the antinociceptive action of THC.


Nov 10, 1976·Psychopharmacology·P P Singh, P K Das
Jul 1, 1975·Journal of Medicinal Chemistry·R S Wilson, E L May
Apr 1, 1973·The Journal of Pharmacy and Pharmacology·J C CradockA M Guarino
Aug 1, 1972·Journal of Neurochemistry·H A SasameG L Gessa
Dec 1, 1972·American Journal of Surgery·N B AckermanN Winer
Dec 1, 1973·British Journal of Pharmacology·G B ChesherG A Starmer
Jan 1, 1972·Psychopharmacologia·D M Buxbaum


Nov 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·A V EremenkoI N Kurochkin
Jan 20, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Anna LeichsenringHermann Lübbert
Jul 21, 1994·European Journal of Pharmacology·S N Thorat, H N Bhargava
Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Rafael Maldonado, O Valverde
Jun 2, 2005·Pharmacology, Biochemistry, and Behavior·D ViganòD Parolaro
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Liana FattoreWalter Fratta
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Eliot L Gardner
Dec 31, 2002·Chemistry and Physics of Lipids·Eliot L Gardner
May 7, 1998·European Journal of Pharmacology·E SpinaG Giagnoni
Jul 3, 1999·Trends in Pharmacological Sciences·J ManzanaresJ A Fuentes
Oct 21, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·M MelisM Diana
Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·F R ButtarelliGuido Palladini
Feb 13, 2001·Progress in Neurobiology·R G Pertwee
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·M Costigan, C J Woolf
Jan 22, 2003·The European Journal of Neuroscience·Anna CastañéRafael Maldonado
Aug 23, 2007·Chemistry & Biodiversity·Barbara Costa
Oct 31, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Carmen WalterJörn Lötsch
Aug 20, 2005·Life Sciences·Dirk G Demuth, Areles Molleman
Apr 9, 2001·Brain Research·F E PontieriF R Patacchioli
Sep 2, 2015·Current Pain and Headache Reports·Bjorn JensenMark Wallace
Aug 6, 2013·Behavioural Brain Research·Maryam FarahmandfarMohammad-Reza Zarrindast
Apr 6, 2017·Cadernos de saúde pública·Luisa María Sánchez-ZamoranoCinthya E Diaz-Benitez
Dec 9, 2014·Behavioural Pharmacology·Harshini NeelakantanEllen A Walker
Apr 1, 1983·Medicinal Research Reviews·R K Razdan, J F Howes
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Diana L Cichewicz, Erin A McCarthy
Aug 1, 1981·Journal of Clinical Pharmacology·P E Gilbert
Nov 18, 2016·Nature·Michael A P BloomfieldOliver D Howes

Related Concepts

Antinociceptive Agents
Brain Chemistry
Drug Tolerance
Mouse, Inbred ICRC
Morphine Sulfate (2: 1), Pentahydrate
Naloxone, (5 beta,9 alpha,13 alpha,14 alpha)-Isomer
Reaction Time
Tetrahydrocannabinol, Trans-(+-)-Isomer

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