A comparison of sotalol and procainamide in symptomatic ventricular tachycardia

Cardiovascular Drugs and Therapy
L JordaensD L Clement

Abstract

The effects of oral sotalol were compared with 1000 and 1500 mg of procainamide in 23 patients with sustained ventricular tachycardia. The predictive value of an induction study after procainamide was assessed. The mean age of the study group was 62 +/- 12 years, and the mean ejection fraction was 32 +/- 16%. The cycle length (CL) of the induced tachycardia, the coupling interval (CI) of the first extrastimulus (in ms), and the number of noninducible (NI) patients are given in the table below. (table; see text) One patient developed torsades during the loading period of sotalol and is included in the number requiring cardioversion (DC). Important proarrhythmic effects (spontaneous occurrence of tachycardia) were seen twice after procainamide. Induction suppression by procainamide predicted success with sotalol (p = 0.0013). Ventricular tachycardia seems to be less often inducible after oral sotalol than after procainamide. The success of procainamide during programmed electrical stimulation predicts the same for sotalol. If ventricular tachycardia remains inducible after oral sotalol, it is faster than after procainamide but slower than the baseline tachycardia. Both drugs slightly prolong refractoriness.

References

Jan 1, 1979·The American Journal of Cardiology·J J LimaW J Jusko
Mar 1, 1985·Progress in Cardiovascular Diseases·S YusufP Sleight
Aug 1, 1985·Journal of the American College of Cardiology·M Mirowski
Aug 1, 1985·Journal of the American College of Cardiology·A P RaeL N Horowitz
Nov 1, 1980·The American Journal of Cardiology·E G GiardinaF I Marcus
Dec 1, 1984·Journal of the American College of Cardiology·F E MarchlinskiM E Josephson
Jun 1, 1984·The American Journal of Cardiology·B McGovernJ N Ruskin
Feb 1, 1983·Journal of the American College of Cardiology·C D SwerdlowJ W Mason
Jun 16, 1983·The New England Journal of Medicine·C D SwerdlowJ W Mason
Sep 1, 1980·The American Journal of Cardiology·A M GreenspanM E Josephson
Dec 1, 1980·The American Journal of Cardiology·T R EngelJ C Luck

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Citations

Jan 5, 1999·Bioorganic & Medicinal Chemistry Letters·M A CurtisE Abushanab
Mar 1, 1995·Pacing and Clinical Electrophysiology : PACE·J P Claudel, P Touboul
Nov 26, 1993·The American Journal of Cardiology·M Nora, D P Zipes

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