A Comparison of Survival Outcomes in Advanced Serous Ovarian Cancer Patients Treated With Primary Debulking Surgery Versus Neoadjuvant Chemotherapy

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Taymaa MayPrafull Ghatage

Abstract

The management of women with advanced-stage serous ovarian cancer includes a combination of surgery and chemotherapy. The choice of treatment with primary debulking surgery or neoadjuvant chemotherapy varies by institution. The objective of this study was to report 5-year survival outcomes for ovarian cancer patients treated at a single institution with primary debulking surgery or neoadjuvant chemotherapy. This study included a retrospective chart review of 303 patients with stage IIIC or IV serous ovarian carcinoma diagnosed in Calgary, Canada. The patients were categorized into 1 of the 2 treatment arms: primary debulking surgery or neoadjuvant chemotherapy. The 5-year ovarian cancer-specific survival rates were estimated using Kaplan-Meier curves. Among the 303 eligible patients, 142 patients (47%) underwent primary debulking surgery, and 161 patients (53%) were treated with neoadjuvant chemotherapy. Five-year survival was better for patients undergoing primary debulking surgery (39%) than for patients who received neoadjuvant chemotherapy (27%; P = 0.02). Women with no residual disease experienced better overall survival than those with any residual disease (47% vs. 26%, respectively; P = 0.0002). This difference was signi...Continue Reading

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Citations

Feb 24, 2018·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Kathryn R TringaleQuyen T Nguyen
Sep 16, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kimberly R JordanBenjamin G Bitler
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Apr 12, 2021·Gynecologic Oncology·Nicole D FlemingAnil K Sood
Sep 25, 2021·Journal of Ovarian Research·Mahak MasoodiGull Mohammad Bhat

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