PMID: 7030729Jan 1, 1980Paper

A comparison of the ability of frog and rat S-9 to activate promutagens in the Ames test

Environmental Mutagenesis
A M ChehR G McKinnell

Abstract

A mutagenesis assay employing the frog, Rana pipiens, is currently under development [McKinnell et al, 1979]. A question that must be answered is whether the frog is metabolically capable of activating a large number of promutagens. The Ames assay offers a simple means of comparing the metabolism of mutagens by different animal species. The Ames response obtained with frog-liver S-9 was compared to the response with rat-liver S-9, using the following compounds: Benzo(a)pyrene, 7,12-dimethylbenz(a)anthracene, 2-amino-fluorene, azobenzene, Sudan II, dibutylnitrosamine, hydrazine sulfate, hydroxyethylhydrazine, cyclophosphamide, 1,2-dichloroethane, tris(2,3 dibromopropyl)phosphate, diallate, quinoline, quercetin, aflatoxin B 1, emodin, and safrole. Of these compounds, activation by rat S-9 was observed for all except hydrazine sulfate and safrole. All except Sudan II, 1,2-dichloroethane, quinoline, and safrole gave positive Ames responses with frog S-9. In general, the responses with frog S-9 were quantitatively lower than those obtained with Aroclor-induced rat S-9; however, the optimum procedure for frog-liver induction has not been determined. The response to dichloroethane is very sensitive to the amount of activating enzyme p...Continue Reading

References

Aug 1, 1979·Acta Pharmacologica Et Toxicologica·E J SøderlundE Dybing
Mar 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Mar 1, 1977·Mutation Research·M NagaoN Ito
Aug 5, 1977·Science·L F Bjeldanes, G W Chang
Mar 1, 1977·Stain Technology·D J Picciano, R G McKinnell
Feb 1, 1978·Journal of the National Cancer Institute·M HollsteinE Wei
Jun 1, 1978·British Journal of Cancer·I F PurchaseF R Westwood
Jan 1, 1979·Mutation Research·T K RaoJ L Epler
Mar 1, 1979·Applied and Environmental Microbiology·F C WehnerM du Rand
Apr 1, 1977·Mutation Research·T YahagiT Sugimura
Jan 7, 1977·Science·A Blum, B N Ames
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesF D Lee

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Citations

Feb 1, 1986·Mutation Research·J M GentileM J Plewa
Aug 9, 2011·Regulatory Toxicology and Pharmacology : RTP·Barry LynchAshley Roberts
Jan 1, 1980·Teratogenesis, Carcinogenesis, and Mutagenesis·R G McKinnellJ W Schaad

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