PMID: 6109741Mar 1, 1981Paper

A comparison of the actions of H1 and H2 antihistamines on histamine-induced bronchoconstriction and cutaneous wheal response in asthmatic patients

The Journal of Allergy and Clinical Immunology
R A NathanA L Schocket

Abstract

The effect of an H1 antihistamine, an H2 antihistamine, and the combination of the two drugs on both histamine-induced bronchoconstriction and dermal whealing was examined in five patients with mild asthma. Chlorpheniramine 8 mg, cimetidine 300 mg, the combination of both, and placebo were administered orally to each patient for a single dose and for seven consecutive doses given every 6 hr after a double-blind, randomized protocol. The airway response to inhaled histamine and the wheal size induced by the intradermal injection of histamine were determined in every patient 2 hr after the final drug dose. The results indicate that a single dose of chlorpheniramine produces a significant increase in the threshold of histamine-induced bronchoconstriction as measured by the provocative histamine dose producing 20% decrease in 1-sec forced expiratory volume (PD20-FEV1), and this effect was significantly enhanced after seven doses. Cimetidine caused a significant decrease in the threshold of histamine-induced bronchoconstriction, but this was not augmented by seven doses. Only chlorpheniramine, when given for seven doses, improved the baseline FEV1 and forced expiratory flow during middle half of forced vital capacity (FEF25%-75%). C...Continue Reading

Citations

Jan 1, 1985·European Journal of Clinical Pharmacology·F P MaesenJ P Rihoux
Feb 1, 1983·Agents and Actions·V HartmannT Ahmed
May 14, 2003·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H Canan HasanogluSemsi Kalkan
Jan 1, 1983·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·J E Selcow
Nov 22, 2018·American Journal of Physiology. Gastrointestinal and Liver Physiology·Zhongcheng ShiJames Versalovic

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