A comparison of the actions of ICI66082 and propranolol on cardiac and peripheral beta-adrenoceptors

European Journal of Pharmacology
B N SinghR M Whitlock


The relative blocking potencies of ICI66082 and propranolol with respect to heart rate contractility, diastolic blood pressure and peripheral vascular conductance were compared in anaesthetized dogs. Peripheral blood flow was measured with an electromagnetic flow-probe around the descending aorta with retrograde cannulation of the inferior mesenteric artery for intra-arterial injections of isoprenaline. Cardiac and peripheral vascular effects of ICI66082 and propranolol were compared in terms of the shifts in the dose--response curves after i.v. and intra-arterial injections of isoprenaline. Propranolol was twice as potent as an equimolar dose of ICI66082 on cardiac beta-adrenoceptors. It was 70--130 times more potent in its action on the peripheral vascular receptors. Propranolol itself was 3 times more potent in blocking peripheral vascular receptors than cardiac beta-receptors. ICI66082 was 17--21 times more active in blocking the myocardial beta-adrenoceptors than those in the peripheral vessels. Electrophysiological studies showed that ICI66082 is devoid of membrane-depressant properties in concentrations up to 100 mg/l.


Apr 1, 1973·The Journal of Clinical Investigation·G BodemC A Chidsey
Aug 1, 1973·British Journal of Pharmacology·E E Bagwell, E M Williams
Feb 10, 1967·Annals of the New York Academy of Sciences·J R Blinks
Sep 26, 1970·British Medical Journal·D J Coltart, D G Shand
Nov 1, 1970·British Journal of Pharmacology·A M Barrett, J Carter
Mar 1, 1971·British Journal of Pharmacology·H E Barber, G R Bourne
Oct 1, 1972·British Journal of Pharmacology·G M Drew, G P Levy
Sep 1, 1966·The American Journal of Cardiology·E M Williams
Aug 1, 1970·British Journal of Pharmacology·B N Singh, E M Vaughan Williams
Jun 1, 1969·British Journal of Pharmacology·A N DohadwallaE M Vaughan Williams
Jun 1, 1965·American Heart Journal·D J PATELE BRAUNWALD
Sep 1, 1949·British Journal of Pharmacology and Chemotherapy·H O SCHILD


Jan 1, 1977·European Journal of Clinical Pharmacology·D L ClementR Pannier
Jan 1, 1981·European Journal of Clinical Pharmacology·M E EllisS H Ellis
Sep 2, 1983·European Journal of Pharmacology·N L Brown, M Worcel
Apr 6, 2002·Reproductive Toxicology·Sonia A Tabacova, Carole A Kimmel
Jul 20, 2002·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·J N Love, J Elshami
Sep 1, 1976·Clinical and Experimental Pharmacology & Physiology·F M WilliamsR Dorrington
Jun 1, 1997·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·W KernsR Raymond
Feb 1, 1978·British Heart Journal·P B DecalmerG M Sterling
Oct 1, 1979·Journal of Neurology, Neurosurgery, and Psychiatry·D JeffersonC D Marsden
Jan 1, 1977·Current Medical Research and Opinion·N K GostickN P Barmer
Aug 31, 1987·The American Journal of Cardiology·F J VendittiJ N Ruskin
Jan 1, 1976·The Journal of International Medical Research·A M HarrisJ A Tweed
Jan 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A LucaJ Rodés
Mar 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·H M Rhee
Jan 1, 1987·Basic Research in Cardiology·B H NeelyL R Smith
Jan 1, 1989·Medical Toxicology and Adverse Drug Experience·J A Critchley, A Ungar
Dec 18, 2019·The Cochrane Database of Systematic Reviews·Sanam SafiChristian Gluud
Nov 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·A JustH Ehmke

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