A comparison of the antimutagenic potential of green, black and decaffeinated teas: contribution of flavanols to the antimutagenic effect

Mutagenesis
A Bu-AbbasC Ioannides

Abstract

The present study was undertaken to compare the antimutagenic activity of aqueous extracts, at the concentrations used for human consumption, from green, black and decaffeinated black tea. Antimutagenic potential was evaluated against three indirect-acting dietary carcinogens, Glu-P-1, benzo(a)pyrene and nitrosopyrrolidine. All three types of tea gave rise to strong and concentration-dependent suppression of the mutagenicity of the three premutagens in the presence of an activation system. No major difference in the antimutagenic potential of the three types of tea could be discerned. Black tea, decaffeinated black tea and, to a lesser extent, green tea also antagonized the mutagenicity of the direct-acting mutagen 9-aminoacridine. All three types of tea inhibited markedly the NADPH-dependent reduction of cytochrome c and the O-dealkylations of ethoxy-, methoxy- and, to a much lesser extent, pentoxy-resorufin. When the microsomal metabolism was terminated, after the metabolic activation of the premutagens, incorporation of the aqueous tea extracts into the activation system caused a concentration-dependent suppression of mutagenic response. No significant difference in the antimutagenic activity of the three types of tea in thi...Continue Reading

Citations

Jul 5, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·F CatterallC Ioannides
Sep 12, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A Bu-AbbasC Ioannides
Sep 9, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T C HourJ K Lin
Jan 21, 2000·Free Radical Biology & Medicine·W Bors, C Michel
Feb 3, 1998·Critical Reviews in Food Science and Nutrition·I E DreostiC S Yang
Mar 7, 2003·Mutagenesis·Fenton CatterallCostas Ioannides
Oct 21, 2005·Journal of Agromedicine·Salil H Patel
Mar 15, 2007·Pakistan Journal of Biological Sciences : PJBS·Sedighe Mehrabian
Oct 15, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Costas Ioannides, Victoria Yoxall
Sep 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Dicson Sheeja MalarTewin Tencomnao
Jan 1, 2016·Comprehensive Reviews in Food Science and Food Safety·Syed M Nasar-AbbasVijay Jayasena
Dec 10, 1999·Journal of Agricultural and Food Chemistry·D M GoldbergG J Soleas

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