PMID: 2505624Aug 1, 1989Paper

A comparison of the antischistosomal effect of levo- and dextro-praziquantel on Schistosoma japonicum and S. mansoni in mice

The American Journal of Tropical Medicine and Hygiene
M TanakaK Yasuraoka

Abstract

Praziquantel (PZQ) is a racemic compound composed of equal proportions of its optical isomers, levo- and dextro-PZQ. The efficacy of these compounds was compared with that of PZQ in mice infected with Schistosoma japonicum or S. mansoni. Mice were given 50, 2 x 50 (on consecutive days), 500, or 2 x 250 mg/kg of each compound orally 5 weeks after infection. Significant reduction of worm recovery was observed in S. japonicum infection 30 days after treatment with 2 x 50, 500, or 2 x 250 mg/kg of levo-PZQ, whereas no therapeutic effect was demonstrated with dextro-PZQ. Percent reduction in worm burden in mice treated with levo-PZQ was significantly higher than in those with PZQ at a dosage of 2 x 50 mg/kg (67.9% vs. 34.5%). Neither eggs in feces nor miracidial hatching of eggs from the livers and intestines were observed in mice treated with levo-PZQ. In S. mansoni infection, levo-PZQ showed no significant schistosomicidal effect compared with PZQ and dextro-PZQ, although there was reduction in egg counts.

Citations

Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·S XiaoM Tanner
Jan 7, 2014·The Journal of Antimicrobial Chemotherapy·Piero OlliaroJennifer Keiser
Sep 29, 2011·PLoS Neglected Tropical Diseases·Michael WoelfleMatthew H Todd
Jul 2, 2014·Antimicrobial Agents and Chemotherapy·Isabel MeisterJennifer Keiser
Sep 28, 2018·Current Medicinal Chemistry·Charlotte M Thomas, David J Timson
Oct 21, 2014·PLoS Neglected Tropical Diseases·Ravi S KasinathanRobert M Greenberg
Dec 28, 2004·International Journal for Parasitology·Robert M Greenberg
Jul 20, 2021·Crystal Growth & Design·Jan-Joris DevogelaerRené de Gelder

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