A comparison of the available phosphodiesterase-5 inhibitors in the treatment of erectile dysfunction: a focus on avanafil

Patient Preference and Adherence
Jeffery D Evans, Stephen R Hill

Abstract

Numerous pathways can lead to erectile dysfunction (ED) in patients, with some patients having multiple causes. Regardless of the etiology, ED has been successfully treated in many patients with the advent of oral phosphodiesterase-5 inhibitors (PDE5Is). With the release of avanafil, there are currently four PDE5I options available, and choosing between them should be based on patient-specific considerations and preferences. To review the treatment of ED with PDE5Is, taking into account the effectiveness, safety, and patient satisfaction of these agents, as well as avanafil's place in therapy. A PubMed search was completed to find articles published in English studying patient satisfaction and adherence to ED medication. Additional searches looked specifically for any data regarding the use of avanafil. ED is effectively treated in most patients with PDE5Is, with the most common side effects from the medications being headache, flushing, and visual disturbances. Patients have identified many different factors, such as efficacy, side effects, duration of action, and daily use, in determining overall satisfaction and the right medication for them. While avanafil does not have any patient satisfaction trials to date, it has been p...Continue Reading

Citations

May 24, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Susann SchröderPeter Brust
May 28, 2016·Expert Review of Clinical Pharmacology·Luca BoeriAndrea Salonia
Sep 30, 2016·Expert Opinion on Pharmacotherapy·Igor VoznesenskyWayne J G Hellstrom
May 4, 2017·Expert Opinion on Investigational Drugs·Li Smith-HarrisonJason R Kovac
Jul 16, 2016·Expert Review of Clinical Pharmacology·Jonathan L ZurawinWayne J G Hellstrom
Sep 1, 2019·Medical Sciences : Open Access Journal·Samir SamiGerald Brock
Nov 13, 2020·International Journal of Clinical Pharmacy·Luis Fernando Valladales-Restrepo, Jorge Enrique Machado-Alba
Sep 3, 2019·The Journal of Allergy and Clinical Immunology·Catherine R WeilerLawrence B Schwartz

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