PMID: 2494347Mar 1, 1989Paper

A comparison of the beta A-and beta B-globin gene clusters of sheep

Journal of Molecular Evolution
K J Garner, J B Lingrel

Abstract

Domestic sheep have two common alleles at the adult beta-globin locus, beta A and beta B. Here we report the structure of the beta-globin locus of A-haplotype sheep. The locus consists of 12 genes, organized as a triplicated 4-gene set: 5' epsilon 1-epsilon II-psi beta I-beta C-epsilon III-epsilon IV-psi beta II-beta A-epsilon V-epsilon VI-psi beta III-beta F 3'. This arrangement is identical to that of the closely related goat locus. Sheep with the B haplotype have a locus arrangement consisting of a duplicated four-gene set, lacking the beta C gene as well as three other genes present in A sheep and goats. In order to understand the evolutionary history of the B sheep locus, we have sequenced the beta B gene from these sheep, and the beta C gene from A-haplotype sheep, and compared the sequences to those of the sheep beta A, goat beta C, and beta A, and cow adult beta genes. Our results indicate that the beta B gene has diverged recently from the beta A gene, and therefore the beta B locus structure may have resulted from a recent deletion from a triplicated locus.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Sep 9, 1986·Biochemistry·A M BrunnerC H Duncan
Nov 29, 1974·Annals of the New York Academy of Sciences·B HammerbergH Kitchen
Nov 1, 1964·The Biochemical Journal·G van Vliet, T H Huisman
Apr 15, 1982·Journal of Molecular Biology·A J JeffreysA C Boyd
Feb 10, 1984·Nucleic Acids Research·J C Schimenti, C H Duncan
Dec 25, 1984·Journal of Molecular Biology·M GoodmanM L Weiss
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T M TownesJ B Lingrel
Jun 1, 1980·Cell·F PerlerJ Dodgson

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Citations

Oct 16, 2004·Journal of Molecular Evolution·Gabriela AguiletaZiheng Yang
May 17, 1994·Biochimica Et Biophysica Acta·J Saban, D King
Jan 1, 1991·Comparative Biochemistry and Physiology. A, Comparative Physiology·B MasalaS Naitana
Jul 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M CordaB Masala
Sep 11, 2008·Molecular Biology and Evolution·Federico G HoffmannJay F Storz
Mar 15, 2006·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·E PieragostiniA Caroli
Sep 12, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Laura MancaBruno Masala
Mar 1, 2007·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Laura MancaBruno Masala

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