A comparison of the cardioselectivity of five beta-adrenoceptor blocking drugs

Journal of Cardiovascular Pharmacology
T H PringleR G Shanks

Abstract

The cardioselectivities of five beta-adrenoceptor antagonists were compared. Six normal subjects received, in a double-blind random order, 200 mg acebutolol, 50 mg atenolol, 10 mg betaxolol, 100 mg metoprolol, 80 mg propranolol, and placebo. All beta-adrenoceptor antagonists produced a similar reduction in exercise tachycardia. Isoprenaline infusions in incremental doses were given. Dose-response curves were constructed and the doses of isoprenaline required to increase heart rate by 25 beats/min (I25), forearm blood flow by 3 ml/100 ml/min (IF3), and finger tremor by 200% (IT200), and decrease diastolic blood pressure by 25 mm Hg (ID25), after each treatment were compared. After propranolol, I25, ID25, IF3, and IT200 were greater (p less than 0.02) than after atenolol, betaxolol, and metoprolol; I25, ID25, and IT200 were greater than after acebutolol. After acebutolol I25, ID25, and IF3 were greater than after atenolol and betaxolol; IT200 was greater than after betaxolol. Atenolol and betaxolol caused less reduction in the isoprenaline-induced changes in blood glucose, plasma potassium, lactate, renin activity, and serum insulin than propranolol. Acebutolol caused less attenuation of blood glucose and plasma lactate, and meto...Continue Reading

Citations

Jan 1, 1991·European Journal of Clinical Pharmacology·B J LipworthD G McDevitt
Jan 1, 1988·European Journal of Clinical Pharmacology·A H DeeringR G Shanks
Jan 1, 1990·Pharmacology & Therapeutics·T H Pringle, J G Riddell
Jan 1, 1990·Pharmacology & Therapeutics·J McAinsh, J M Cruickshank
Jul 1, 1990·British Journal of Clinical Pharmacology·N A IrvineD G McDevitt
Aug 1, 1990·British Journal of Clinical Pharmacology·C Funck-BrentanoR L Woosley
Feb 1, 1991·British Journal of Clinical Pharmacology·B J LipworthD G McDevitt

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