A comparison of the changes in cardiac output and systemic vascular resistance during exercise following high-fat meals containing DHA or EPA

The British Journal of Nutrition
Victoria G RontoyanniThomas A B Sanders

Abstract

Long-chain n-3 PUFA can lower blood pressure (BP) but their acute effects on cardiac output, BP and systemic vascular resistance (SVR) in response to dynamic exercise are uncertain. We compared the effects of high-fat meals rich in EPA (20 : 5n-3), DHA (22 : 6n-3) or oleic acid (control) on cardiac output, BP and SVR in response to exercise stress testing. High-fat meals (50 g fat) containing high-oleic sunflower oil enriched with 4·7 g of either EPA or DHA v. control (high-oleic sunflower oil only) were fed to twenty-two healthy males using a randomised cross-over design. Resting measurements of cardiac output, heart rate and BP were made before and hourly over 5 h following the meal. A standardised 12 min exercise test was then conducted with further measurements made during and post-exercise. Blood samples were collected at fasting, 5 h postprandially and immediately post-exercise for the analysis of lipid, glucose and 8-isoprostane-F2α (8-iso-PGF2α). Plasma concentrations of EPA and DHA increased by 0·22 mmol/l 5 h following the EPA and DHA meals, respectively, compared with the control (P < 0·001). Resting cardiac output and 8-iso-PGF2α increased similarly following all meals and there were no significant differences in ca...Continue Reading

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Citations

Oct 25, 2012·Plant Foods for Human Nutrition·Aarati Susan MathewWendy L Hall
Aug 6, 2015·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Victoria G RontoyanniWendy L Hall
Jun 4, 2016·The British Journal of Nutrition·Behnam TajikJyrki K Virtanen
Feb 10, 2018·International Journal of Molecular Sciences·Jacqueline K Innes, Philip C Calder
Feb 9, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Jordan B LeePhilip J Millar
Nov 30, 2018·Research in Sports Medicine·Jordan D PhilpottStuart D R Galloway
Jan 29, 2021·EFSA Journal·UNKNOWN EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Helle Katrine Knutsen
Dec 8, 2016·Metabolism: Clinical and Experimental·Mariasole Da BoitStuart R Gray

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