PMID: 8608360Dec 1, 1995Paper

A comparison of the effectiveness and cost of treatment for vertebral fractures in women

British Journal of Rheumatology
R M FrancisD J Torgerson

Abstract

Of the treatments available for the management of established vertebral osteoporosis, hormone replacement therapy (HRT), intermittent cyclical etidronate therapy and salmon calcitonin have been shown in randomized, controlled trials to reduce the risk of further vertebral fractures. In order to compare the cost effectiveness of these different treatments we examined the cost and efficacy of each treatment using previously published data. HRT, cyclical etidronate and salmon calcitonin all decrease the incidence of further vertebral fracture by 50-60%. Estimation of the cost per vertebral fracture averted therefore reflects the underlying cost of medication, with HRT costing 138-680 pounds per fracture averted compared with 1880 pound for cyclical etidronate therapy and 9075-25 013 pounds for salmon calcitonin therapy. HRT is therefore the treatment of choice for post-menopausal women with osteoporosis, particularly as it may also decrease the risk of ischaemic heart disease. Although salmon calcitonin appears as effective as the other treatments, it is considerably more expensive, so should be reserved for situations where HRT and cyclical etidronate are inappropriate.

Citations

Jun 28, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Rachael L FleurenceDavid J Torgerson
Mar 1, 1997·Endocrinology and Metabolism Clinics of North America·T N Taylor, E A Chrischilles
Nov 24, 2007·Ortopedia, traumatologia, rehabilitacja·Edward CzerwińskiMagdalena Kołacz
Jun 26, 2013·British Journal of Anaesthesia·E J Dansie, D C Turk
Jul 15, 2011·Rheumatology·William TillettNeil J McHugh
Mar 4, 1998·Australian and New Zealand Journal of Medicine·I R Reid
Jun 5, 1998·Annual Review of Public Health·J D GrahamM C Weinstein
Nov 4, 2009·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Melissa ThompsonHans Peter Kruse
Nov 18, 2000·Arthritis Care and Research : the Official Journal of the Arthritis Health Professions Association·A CranneyP Tugwell
Mar 17, 2012·The Journal of Rheumatology·Ying-Ying LeungEdmund Kwok-Ming Li
May 4, 2017·The Journal of Rheumatology·Alexis OgdieAna-Maria Orbai
Feb 6, 2017·The Journal of Rheumatology·Ana-Maria OrbaiAlexis Ogdie
Jul 3, 2010·The Journal of Rheumatology·Janice A HustedDafna D Gladman
Jul 17, 2016·The Journal of Rheumatology·Barry J SheaneVinod Chandran
Jun 3, 2015·The Journal of Rheumatology·Enrique R Soriano
Jun 17, 2018·The Journal of Rheumatology·Alberto CauliUNKNOWN GRAPPA 3PPsA Study Group
Dec 3, 2015·The Journal of Rheumatology·Alberto Cauli, Matteo Piga
Mar 3, 2011·The Journal of Rheumatology·Philip J Mease, Dafna D Gladman
Mar 3, 2011·The Journal of Rheumatology·Philip S HelliwellPhilip J Mease
Mar 3, 2011·The Journal of Rheumatology·Philip J Mease
Jun 3, 2014·The Journal of Rheumatology·Christopher T Ritchlin
Feb 12, 2010·The Journal of Rheumatology·Dafna D Gladman
Sep 17, 2018·The Journal of Rheumatology·Laura C CoatesPhilip S Helliwell
Oct 31, 2017·Annals of the Rheumatic Diseases·Leonieke J J van MensLaura C Coates
Jul 28, 2017·Annals of the Rheumatic Diseases·William TillettUNKNOWN GRAPPA OMERACT Psoriatic Arthritis working group
Mar 10, 1998·British Journal of Clinical Pharmacology·R M Francis
May 3, 2016·The Journal of Rheumatology·Dafna D GladmanKristina Callis Duffin

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