A comparison of the effects of 6-beta naltrexol and naltrexone on the consumption of ethanol or sucrose using a limited-access procedure in rats

Pharmacology, Biochemistry, and Behavior
Michael F StrombergCharles P O'Brien

Abstract

We recently reported that 6-beta naltrexol, the major metabolite of naltrexone in humans, reduced ethanol consumption in rats. Two new experiments were designed to compare 6-beta naltrexol and naltrexone across three dose levels on an ethanol or sucrose baseline using a limited-access procedure in Wistar rats. The results of Experiment 1 showed that both 6-beta naltrexol and naltrexone reduced ethanol consumption across a range of doses. An in vivo assay showed that naltrexone was approximately 25 times more potent than 6-beta naltrexol at comparable ED50 doses. In addition, there was no indication of systematic development of tolerance to the effect of either drug across the 4 days of drug administration. In Experiment 2, both 6-beta naltrexol and naltrexone reduced the consumption of a sucrose solution using a limited-access procedure. The implications of these data for the development of pharmacotherapeutic agents capable of reducing drinking in recovering alcoholics are discussed.

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Citations

Mar 25, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Emmanuelle Simon O'BrienMickaël Naassila
Aug 16, 2005·CNS Drugs·Vania Modesto-Lowe, Eleanor M Fritz
Jul 13, 2007·Proceedings of the National Academy of Sciences of the United States of America·Pia SteenslandSelena E Bartlett
Jul 30, 2005·Journal of Pharmaceutical Sciences·Kalpana S PaudelAudra L Stinchcomb
Oct 16, 2018·Alcoholism, Clinical and Experimental Research·Alessandra MatzeuRemi Martin-Fardon
Nov 18, 2006·Journal of Clinical Psychopharmacology·Helen M PettinatiCharles A Dackis
Feb 3, 2007·The Journal of Pharmacology and Experimental Therapeutics·Danxin WangWolfgang Sadee
May 20, 2015·British Journal of Pharmacology·Florence NobleNicolas Marie
Aug 24, 2017·Alcoholism, Clinical and Experimental Research·Bo SöderpalmMia Ericson
Apr 8, 2011·British Journal of Pharmacology·Tamzin L Ripley, David N Stephens
Mar 19, 2019·Neuropharmacology·Sophie LebourgeoisCatherine Vilpoux

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