A comparison of the effects of botulinum toxin A and steroid injection on nasal allergy

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Tae Yong YangTae Young Jang

Abstract

To compare the effects of botulinum toxin A (BTX-A) with intranasal steroid injections on nasal symptoms in patients with allergic rhinitis (AR). A randomized, placebo-controlled, single-blinded clinical trial (patients were blinded). Thirty-nine patients were included in the study. AR was diagnosed by means of history, clinical examination, and skin prick test. Patients were randomly divided into three subgroups as follows: in group A, 25 units of BTX-A were injected into each inferior turbinate (total 50 units); in group B, 1 cc (20 mg/mL) of triamcinolone was injected into each inferior turbinate; and in group C, 1 cc of isotonic saline was injected as placebo. The symptoms of AR were scored by the patient on a six-point scale. At all time points, group A was significantly better than group C. In the nasal obstruction and rhinorrhea scores, group A was significantly better than group B after 8 weeks. BTX-A may provide better AR symptom relief in terms of duration and degree than a steroid injection.

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Citations

Oct 20, 2009·Head & Face Medicine·Saskia RohrbachRainer Laskawi
Apr 25, 2013·Allergology International : Official Journal of the Japanese Society of Allergology·Sayyed Mostafa HashemiMahdi Pourghasemian
Nov 28, 2012·Toxicon : Official Journal of the International Society on Toxinology·Markus NaumannDaniel Truong
Jul 28, 2016·Current Allergy and Asthma Reports·Cengiz Ozcan, Onur Ismi
Dec 13, 2012·American Journal of Rhinology & Allergy·Zhao ZhuCurtis L Ruegg
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Jan 19, 2021·International Forum of Allergy & Rhinology·Ashleigh A Halderman
May 7, 2021·International Forum of Allergy & Rhinology·Kencho RinzinKornkiat Snidvongs

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