PMID: 8969391Dec 1, 1996Paper

A comparison of the effects of propofol-alfentanil versus isoflurane anesthesia on arterial oxygenation during one-lung ventilation

Journal of Cardiothoracic and Vascular Anesthesia
C W ReidS Lenis

Abstract

To determine whether intravenous propofol-alfentanil anesthesia provides superior arterial oxygenation (Pao2) during one-lung ventilation (OLV) compared with isoflurane inhalation anesthesia. A prospective, randomized, cross-over study. Tertiary-care university hospital. Thirty adults having either thoracoscopic pulmonary surgery or esophageal surgery. Patients received either propofol-alfentanil infusion anesthesia or one minimum alveolar concentration (MAC) of isoflurane during the initial period of two-lung ventilation and the first 30 minutes of OLV and then were switched to the other anesthetic for the duration of OLV. Arterial blood gases and hemodynamics were recorded during two-lung ventilation and after 20 and 30 minutes of OLV with each anesthetic technique. The mean values (+/- SD) for Pao2 during propofol-alfentanil anesthesia after 20 minutes (222 +/- 100) and 30 minutes (228 +/- 102 mmHg) of one-lung ventilation were not significantly different than after 20 minutes (213 +/- 99) or 30 minutes (214 +/- 96 mmHg) of isoflurane; beta error less than 0.1. Mean heart rate was lower during intravenous (78 +/- 15 min) than inhalation (85 +/- 17 min) anesthesia (rho = 0.03). This study does not support the theory that tota...Continue Reading

References

Apr 1, 1990·Journal of Cardiothoracic Anesthesia·P A Steegers, P J Backx
Jan 1, 1989·Journal of Clinical Anesthesia·L Van KeerT Lerut
Apr 1, 1986·Anesthesiology·K B DominoB E Marshall
Dec 1, 1985·Anesthesiology·R F Grover
Feb 1, 1995·British Journal of Anaesthesia·J GrohA E Goetz

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Citations

Jun 4, 2005·Der Anaesthesist·J MotschJ Roggenbach
Jan 16, 2008·Current Opinion in Anaesthesiology·Andrew Ian LevinAndre Coetzee
Dec 3, 1998·Acta Anaesthesiologica Scandinavica·D SatohY Hashimoto
Nov 24, 2004·Thoracic Surgery Clinics·Philip M Hartigan, Ju-Mei Ng
Sep 11, 2013·Journal of Cardiothoracic and Vascular Anesthesia·Silvia BermejoMargarita M Puig
Aug 12, 2014·Pharmacology & Therapeutics·Andrea OlschewskiHorst Olschewski
Jul 1, 2006·Anesthesiology·Peter D Slinger
Jul 25, 2006·Anesthesia and Analgesia·Peter Slinger
May 7, 2009·Anesthesiology·Waheedullah Karzai, Konrad Schwarzkopf
Jun 7, 2019·Anaesthesia and Intensive Care·Philip J PeytonBruce R Thompson
Jan 15, 2015·Anesthesiology·Andrew B Lumb, Peter Slinger
Jul 13, 2013·The Cochrane Database of Systematic Reviews·Norma S P MódoloRegina P El Dib

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