A comparison of the effects of propofol and etomidate on the induction of anesthesia and on cardiopulmonary parameters in dogs

Veterinary Anaesthesia and Analgesia
Lisa SamsErik Hofmeister

Abstract

To determine the effects of propofol or etomidate on induction quality, arterial blood pressure, blood gases, and recovery quality in normal dogs. Randomized, blinded trial. Eighteen purpose-bred adult Beagles. Dogs were randomly assigned to receive propofol at 8 mg kg(-1) or etomidate at 4 mg kg(-1) intravenously (IV) administered to effect. Midazolam was administered at 0.3 mg kg(-1) IV as pre-medication at least 1 minute prior to induction. Direct arterial blood pressure, arterial blood gases, and heart rate were obtained at baseline, before induction, after induction, and for every 5 minutes afterwards until the dog began to swallow and the trachea was extubated. The dogs were allowed to breathe room air with the endotracheal tube in place. The systolic arterial pressure (SAP) was higher in the etomidate group compared with the propofol group after induction. The SAP and mean arterial pressure (MAP) were higher in the etomidate group compared with the propofol group at 5 minutes. The recovery quality and ataxia score were worse in the etomidate group compared with the propofol group. Time from extubation to sternal recumbency and sternal recumbency to standing was longer in the etomidate group compared with the propofol gro...Continue Reading

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Citations

Dec 14, 2011·Fish Physiology and Biochemistry·Inger Hilde ZahlAnders Kiessling
Apr 17, 2015·Veterinary Anaesthesia and Analgesia·Eduardo R MonteiroBetânia S Monteiro
Mar 13, 2012·Veterinary Anaesthesia and Analgesia·Juan Morgaz RodríguezMaría M Granados Machuca
Jan 22, 2013·Veterinary Anaesthesia and Analgesia·Jill K ManeyErik H Hofmeister
Oct 20, 2010·Journal of Veterinary Emergency and Critical Care·Birgit PuschnerElizabeth R Tor
May 20, 2014·Veterinary Anaesthesia and Analgesia·Ana M del ÁlamoMark E Payton
Jun 4, 2014·Veterinary Anaesthesia and Analgesia·Fernando Martinez-Taboada, Elizabeth A Leece
Aug 13, 2014·Veterinary Anaesthesia and Analgesia·Jeong-Im SeoChangbaig Hyun
Jun 25, 2014·The Veterinary Record·S Sanchis-MoraH I Alibhai
Aug 30, 2017·The Veterinary Record·Sandra D TaylorAudrey Ruple
Sep 14, 2018·BMC Veterinary Research·Andrea CattaiPaolo Franci
Aug 15, 2020·Veterinary Anaesthesia and Analgesia·Carmelo ParisiAlastair Mair
Aug 3, 2021·Frontiers in Veterinary Science·Zhiheng ZhangLi Gao
Apr 11, 2013·Veterinary Anaesthesia and Analgesia·Andrea SánchezFrancisco G Laredo
Aug 28, 2009·Veterinary Anaesthesia and Analgesia·Erik H HofmeisterPhillip Anthony Moore

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