PMID: 7022537Jan 1, 1981Paper

A comparison of the effects of prostaglandins E2 and I2 on renal function and renin release in salt-loaded and salt-depleted anaesthetized dogs

Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society
R L JonesA Ungar

Abstract

Prostaglandin E2 (PGE2) and prostaglandins I2 (PGI2) were infused into the renal artery of either sodium-loaded or sodium-depleted dogs. Systemic blood pressure was decreased and arterial plasma renin concentration increased in the sodium-loaded dogs by infusion of PGI2 (1200 ng/min). Both compounds increased renal blood flow but PGE2 had a much more potent effect than PGI2 on increasing urine flow and sodium excretion. In the sodium-depleted dogs systemic blood pressure was significantly decreased and arterial plasma renin concentration increased by infusions of PGI2 (300 and 1200 ng/min) and PGE2 (300 ng/min). Both compounds stimulated urine flow and renal blood flow but PGE2 induced a much larger increase in sodium excretion than PGI2. PGI2 exerts its actions on renal function by inducing vasodilatation whereas PGE2 also has a direct action on tubular function.

Citations

Aug 1, 1989·Baillière's Clinical Endocrinology and Metabolism·P L Padfield
Jun 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·C J Lote, J Haylor
Aug 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·D A JenkinsB F Clarke
Jun 1, 1986·Acta Physiologica Scandinavica·J F BuggeF Kiil
Jan 1, 1988·European Journal of Clinical Pharmacology·D A JenkinsM L Watson
Jun 15, 2012·American Journal of Hypertension·Tianxin Yang, Yaomin Du

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