A comparison of the effects of three positive inotropic agents (amrinone, milrinone and medorinone) on platelet aggregation in human whole blood

Thrombosis Research
A PattisonF W Bonner

Abstract

Amrinone, milrinone and medorinone inhibit platelet aggregation in human whole blood. They are particularly potent inhibitors of arachidonic acid induced aggregation, inhibiting by 50% (IC50) at concentrations of 1.5 microM (milrinone), 7.5 microM (medorinone) and 48 microM (amrinone). Each drug was less potent at inhibiting ADP and collagen-induced aggregation. The rank order for inhibition of arachidonic acid - induced aggregation correlated well with the rank order of cyclic AMP phosphodiesterase inhibition for these drugs when compared to the response of a reference cAMP phosphodiesterase inhibitor (CI-930) and a reference cGMP phosphodiesterase inhibitor (M & B 22948). Since inhibition of platelet aggregation in vitro occurred at clinically relevant concentrations, it is evident that these agents have potentially beneficial antithrombotic properties.

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Citations

Jun 22, 2002·Journal of Hepatology·Takashi KobayashiMasatoshi Makuuchi
Sep 15, 2004·Journal of Cardiothoracic and Vascular Anesthesia·Francesco OnoratiMaurizio Cotrufo
Feb 9, 2002·The Annals of Thoracic Surgery·Jerrold H LevyG Michael Deeb
Jan 26, 2012·Seminars in Cardiothoracic and Vascular Anesthesia·Julie HuffmyerJ Michael Jaeger
Jul 1, 1995·Anesthesia and Analgesia·M KikuraJ H Levy
Apr 18, 2009·Anesthesia and Analgesia·Mark C WesleyJames A Dinardo
Jan 16, 1999·Journal of Cardiovascular Pharmacology·T KerttulaS Kaukinen

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