PMID: 7545448Jun 1, 1995Paper

A comparison of the effects of tranexamic acid and low-dose aprotinin on blood loss and homologous blood usage in patients undergoing cardiac surgery

Journal of Cardiothoracic and Vascular Anesthesia
S C Pugh, A K Wielogorski

Abstract

To assess the relative efficacy of a "low-dose" aprotinin regimen and tranexamic acid on blood loss and homologous blood usage in patients undergoing primary cardiac surgery. The trial was prospective, randomized, and controlled. A single center study in a regional cardiothoracic unit in the UK. 75 Patients, age 18 years or over, who were scheduled for routine primary cardiac surgery. The patients were randomly allocated to receive neither drug nor placebo, a total of 5 g of tranexamic acid, or a total of 2 x 10(6) kallikrein inhibitory units of aprotinin in the perioperative period. The volume of blood loss and blood replacement were measured in the operative and postoperative periods. Hemoglobin concentration, platelet count, and white cell counts were determined preoperatively and at 24 hours postoperatively. Patients receiving tranexamic acid or aprotinin showed a significant reduction in postoperative blood loss (median[interquartile range] 375 mL [252 to 542] and 230 mL [137 to 547]), respectively, compared with the control group (615 mL [430 to 861]). Blood usage was also reduced in patients in both the tranexamic acid group (600 mL [415 to 800]) and the aprotinin-treated group (420 mL [350 to 887]) compared with the con...Continue Reading

References

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Citations

Apr 10, 1999·The Annals of Thoracic Surgery·L M JacquetR A Dion
Apr 6, 2000·The Annals of Thoracic Surgery·B I WongB S Goldman
Jun 1, 2007·The New England Journal of Medicine·Pier Mannuccio Mannucci, Marcel Levi
Aug 2, 2002·Anesthesiology·Noreen P DowdJohn Butterworth
Jun 19, 2004·International Anesthesiology Clinics·Andrew Maslow, Carl Schwartz
Jan 29, 2003·Heart Disease·Sheldon Goldstein, David Amar
May 23, 2012·BMJ : British Medical Journal·Katharine KerIan Roberts
Jul 1, 1996·Anesthesia and Analgesia·L Shore-LessersonM A Ergin
Aug 21, 2008·Anesthesia and Analgesia·Chinnamuthu MurugesanKanchi Muralidhar
Nov 28, 2001·The Annals of Thoracic Surgery·G J DespotisC W Hogue
Mar 16, 2001·Expert Opinion on Pharmacotherapy·P P PunjabiK M Taylor
Apr 1, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Gregory A NuttallWilliam C Oliver
Jan 25, 2007·Asian Cardiovascular & Thoracic Annals·Aflatoon Mehr-AeinManouchehr Madani-Civi
Nov 11, 2005·Clinical Trials : Journal of the Society for Clinical Trials·Dean FergussonStan Shapiro
Oct 6, 2017·The Open Orthopaedics Journal·Joao Paulo Fernandes GuerreiroDaniele Cristina Cataneo
Sep 23, 1997·American Journal of Hematology·T F Slaughter, C S Greenberg
Jan 20, 2004·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·L T Goodnough, G J Despotis
Apr 27, 2001·Anesthesia and Analgesia·B K FiechtnerM H Ereth

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