A comparison of the effects of tributyltin chloride and triphenyltin chloride on cell proliferation, proapoptotic p53, Bax, and antiapoptotic Bcl-2 protein levels in human breast cancer MCF-7 cell line

Toxicology in Vitro : an International Journal Published in Association with BIBRA
Maria FickovaJulius Brtko

Abstract

In recent years it was disclosed, that numerous organotin(IV) derivatives have remarkable cytotoxicity against several types of cancer cells. The property to inhibit cell growth makes these compounds promising for antitumor therapy, as the clinical effectiveness of cisplatin is limited by drug resistance and significant side effects. Tributyltin and triphenyltin are known as endocrine disruptors. Moreover, the compounds exert their toxicity in mammals predominantly through nuclear receptor signaling. Here we present the effects of tributyltin chloride (TBT-Cl) and triphenyltin chloride (TPT-Cl) on cell proliferation, expression of proapoptotic p53, Bax, and antiapoptotic Bcl-2 proteins in human breast cancer MCF-7 cell line. Dose and time dependent (24, 48 and 72 h) cell expositions have demonstrated TBT-Cl as more effective in inhibiting MCF-7 cell proliferation than TPT-Cl. Short time treatment with TBT-Cl displayed marked stimulation of p53 protein expression when compared to TPT-Cl. Both organotin compounds displayed similar mild enhancement of Bax protein expression. The 24h exposition of TPT-Cl induced substantial diminution of Bcl-2 protein expression in comparison with both, untreated cells and TBT-Cl treated cells. Our...Continue Reading

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Citations

Jan 24, 2016·Chemosphere·Pearl U OfoegbuJoão L T Pestana
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Luba HunakovaJ Brtko
Jan 21, 2017·Oncoscience·Stefanie B Marquez-VilendrerDavid N Reisman
Oct 23, 2015·American Journal of Physiology. Cell Physiology·Shanshan SongJason X-J Yuan
Jul 29, 2015·World Journal of Gastroenterology : WJG·Hai-Bo ZhouZhi-Gang Chen
May 5, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Viera BohacovaAlbert Breier
Aug 10, 2021·Frontiers in Chemistry·Sharifah Nadhira Syed AnnuarKok Meng Chan

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